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Notch-mTOR信号介导的免疫反应与能量代谢轴：中医药预防IBD复发的可能关键
, 2016 炎症性肠病（inflammatory bowel disease,IBD）是世界性难治性疾病,其难治在于高复发率.中医药治疗IBD疗效高且复发率低,但作用机制不明,然Notch与mTOR信号间相互关联,且通过各种途径调控机体免疫水平和细胞能量代谢变化,并与IBD的发作密切相关,提示调控Notch-mTOR信号介导免疫与能量轴变化可能是探索中医药预防和防止IBD复发的可能突破口和有效策略.
刘端勇, 赵海梅
semanticscholar +1 more source
The metabolic profilings study of serum and spinal cord from acute spinal cord injury rats ^1H NMR spectroscopy [PDF]
, 2017 目的：采用-1H NMR核磁共振代谢组学的方法研究急性脊髓损伤模型大鼠的代谢组学特征及生物标志物,探讨核磁共振代谢组学应用于脊髓损伤研究的可行性。方法：取8周龄清洁级雄性SD大鼠20只,体重（200±10）g,按照随机数字法分为假手术组和模型组,每组10只,模型组采用改良的Allens法制作急性脊髓不完全损伤模型,假手术组不损伤脊髓,术后第1、5、7天采用BBB运动功能评分法进行行为学观察,术后第7天收集脊髓组织作病理学观察,核磁共振代谢组学对两组大鼠血清和脊髓样本进行代谢组学分析。结果 ...
全仁夫 +4 more
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Production of 1,3-Propanediol from Raw Glycerol by Biocatalytic Transformation [PDF]
, 2013 1，3-丙二醇（1，3-PD）是一种重要的化工原料，具有广泛的应用领域。发酵法生产1，3-PD以利用可再生资源等优点日益受到重视。大部分研究以纯甘油为底物，成本高，如果以粗甘油为底物，可大大降低生产成本。 本论文的研究目的是以粗甘油为底物，以Clostridiumbutyricum（丁酸梭状芽孢杆菌）为生产菌株，通过厌氧发酵生产1，3-PD，在粗甘油预处理、提高菌体浓度、提高单位菌体生产能力、延长发酵周期和建立动力学模型这几个方面进行了研究，主要结果如下： （1 ...
朱春杰
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Integrative Conservation, Volume 3, Issue 3, Page 168-182, September 2024.Using long‐term field data, we examined the impact of severe droughts on the health, reproductive success, and behavior of the critically endangered Verreaux's sifaka (Propithecus verreauxi) in Madagascar's seasonally dry tropical forest. Despite reduced availability of high‐quality foods, sifaka exhibited stable body condition and reproductive success,
Carrie C. Veilleux +2 more
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宏基因组联合UPLC-Q-TOF-MS/MS探讨地塞米松对大鼠肺炎的作用机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的基于多组学技术，探讨地塞米松（Dex）能否通过调节肠道菌群及代谢物治疗肺炎。方法将18只Sprague-Dawley大鼠随机均分为对照（Control）组、模型（Model）组和地塞米松（Dex）组，每组6只，除Control组外，余下两组持续使用4 mg/kg的脂多糖（LPS）腹腔注射7 d建立大鼠肺炎模型。然后Dex组给予2 mg/kg的Dex灌胃治疗12 d，余下两组均连续灌胃等量的无菌PBS缓冲液12 d。第19 d时收集大鼠的肺组织、血浆、粪便和肠道内容物。苏木精-伊红（H&E ...
李四菊 +5 more
doaj
Changes on Mitochondrial DNA Content in Non-small Cell Lung Cancer [PDF]
, 2011 Background and objective It has been proven that the mitochondrial DNA (mtDNA) mutations and content change were associated with increasing risk of tumorigenesis. MtDNA content is significantly reduced in most substantive tumors. The aim of this study is
Hongmei WANG, Jigang DAI
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Integrative Conservation, Volume 3, Issue 3, Page 257-270, September 2024.Natural training enclosure design schematic. We selected 12 sika deer including six adults and six sub‐adults. Key considerations in the design of the natural training were to divide the training spatial ground into two parts (30 × 30 m small areas for isolation of new individuals and large areas measuring 200 × 600 m for free walking), and the ...
Wentao Zhang +10 more
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Metaproteomic study of marine phytoplankton blooms [PDF]
, 2015 浮游植物是海洋初级生产力的主要贡献者，也是海洋食物链的重要组成，在海洋碳循环、生态系统维持和全球气候调节中起着重要作用。浮游植物藻华，特别是高频发生的甲藻和硅藻藻华，深刻地影响着海洋生态系统、全球气候以及人类健康。目前在浮游植物藻华形成的生态学和海洋学机制方面开展了大量工作，但我们对藻华形成的分子机制知之甚少。 本论文将宏蛋白质组学理念和方法应用于海洋浮游植物藻华研究，结合生物信息学分析手段，建立了海洋浮游植物藻华宏蛋白质组学研究方法，比较研究了藻华爆发区与非藻华区 ...
张浩
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Effect of Lactobacillus acidophilus M6 on Improving Exercise Performance and Relieving Fatigue in Mice [PDF]
, 2023 Objective: To isolate Lactobacillus acidophilus M6 from the feces of long-distance runners in the early stage. The aim of this study was to investigate the effect of Lactobacillus acidophilus M6 on improving exercise ability and alleviating fatigue ...
Ming FU, Yanqing ZANG
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Effects of Prorocentrum micans on survival and development of different ecological habits copepods and proteomics analysis [PDF]
, 2016 本文运用实验生态方法研究了海洋原甲藻（Prorocentrummicans）对3种不同生态习性桡足类[日本虎斑猛水蚤（Tigriopusjaponicus）、婆罗异剑水蚤（Apocyclopsborneoensis）和太平洋纺锤水蚤（Acartiapacifica）]不同发育阶段的存活率和发育时间的影响，通过太平洋纺锤水蚤五个世代的连续培养，分析了多世代培养条件下太平洋纺锤水蚤对不同浓度海洋原甲藻的适应能力；同时，采用蛋白质组学及生物信息学方法 ...
贾启龙
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