Results 21 to 30 of about 4,934 (166)

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能

Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022
Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya, Sheila Donnelly, Bronwyn O'Brien   +2 more
wiley   +1 more source

Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients 糖尿病和非糖尿病患者腹部皮下和内脏脂肪组织神经酰胺的变化

Journal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022
Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori, Michael H. Wood, Stephanie C. Tucker, Krishna Rao Maddipati, S. Kiran Koya, Gregory W. Auner, Kenneth V. Honn, Berhane Seyoum   +7 more
wiley   +1 more source

New clusters of serum electrolytes aid in stratification of diabetes and metabolic risk 聚类分析显示血清电解质簇有助于糖尿病及代谢异常风险人群分层

Journal of Diabetes, Volume 14, Issue 2, Page 121-133, February 2022., 2022
Highlights Three identified clusters based on seven commonly measured serum electrolytes had different metabolic profiles, associated with distinct risk of developing diabetes and progression of glucose and lipid metabolic traits. Individuals in Cluster A were older, more were women, and had “normal” to low risk for diabetes.
Yanan Hou, Jiali Xiang, Huajie Dai, Tiange Wang, Mian Li, Hong Lin, Shuangyuan Wang, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Zhiyun Zhao, Yufang Bi, Min Xu   +14 more
wiley   +1 more source

Tree species richness differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Journal of Ecology, Volume 110, Issue 1, Page 97-116, January 2022., 2022
In the BEF‐China experiment, metabolomics samples were collected from four different species and three organs (a). The metabolomes are species and organ specific (b), and the metabolome specificity is attributed to different chemical classes (c). Tree species diversity affects the metabolome composition (d), but more controlled interaction experiments ...
Alexander Weinhold, Stefanie Döll, Min Liu, Andreas Schedl, Yvonne Pöschl, Xingliang Xu, Steffen Neumann, Nicole M. van Dam   +7 more
wiley   +1 more source

Relationships between fasting glucose levels, lifestyle factors, and metabolic parameters in Korean adults without diagnosis of diabetes mellitus 未诊断糖尿病的韩国成年人空腹血糖水平、生活方式因素和代谢参数之间的关系

Journal of Diabetes, Volume 14, Issue 1, Page 52-63, January 2022., 2022
Highlights The proportions of individuals with obesity, abdominal obesity, and heavy drinking increased according to fasting glucose level. The risk for uncontrolled blood pressure and lipid profiles increased with increasing fasting glucose levels.
Seo Young Kang, Young Sik Kim
wiley   +1 more source

MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大

, 2022
Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
wiley   +1 more source

Associations of sugar-sweetened beverages intake frequency with physical growth and glucolipid metabolism among children and adolescents [PDF]

, 2023
BackgroundChildren and adolescents drink sugar-sweetened beverages (SSBs) frequently. Research has confirmed that SSBs associate with weight gain and overweight or obesity.
Jiajie ZANG, Liping SHEN, Mengying QU, Qi SONG, Shupeng MAI, Wei LU, Zehuan SHI, Zhengyuan WANG, Zhenni ZHU, Zhuo SUN   +9 more
core   +1 more source

Study on the mechanism of FBXW7 protects against insulin resistance via regulating FetuinA protein level [PDF]

, 2016
目的：FBXW7属于SCF类泛素连接酶E3，可调控脂质代谢关键转录因子和胰岛功能相关蛋白的泛素化降解。FetuinA是一类参与机体糖脂代谢调控的重要肝脏因子，与胰岛素抵抗发生密切相关，但在肥胖状态下肝脏中蛋白水平异常升高机制不得而知。本研究拟探究FBXW7在肥胖状态下对FetuinA蛋白水平调节机制，有助于进一步完善肥胖致胰岛素抵抗机制。 方法：本课题结合高脂饮食诱导的HFD肥胖小鼠模型和正常饮食诱导的ob/ob小鼠肥胖模型，检测小鼠糖脂代谢相关指标，采用Real-timePCR和ELISA ...
刘祺
core  

Plant–microbe interactions drive the rhizosphere microbial assembly and nitrogen cycling in a subtropical forest

Functional Ecology, Volume 39, Issue 5, Page 1274-1287, May 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between plants and soil microorganisms in the rhizosphere are vital for maintaining the nutrient cycle and stability of terrestrial ecosystems. Nitrogen, closely related to carbon (C) cycling and ecosystem productivity, undergoes transformation by soil ...
Ru Wang, Yang Chen, He Zhang, Zihua Wang, Fangyuan Zheng, Yutian Mu, Hanzhi Bao, Zilong Ma, Chengjin Chu, Yuchun Yang   +9 more
wiley   +1 more source

The preliminary study on the dyslipidemia in rats with autoimmune myocarditis [PDF]

, 2016
目的：心肌炎是心肌间质中局限或弥漫性的急性或慢性炎症，目前关于心肌炎中血脂代谢的相关研究较少，本课题通过建立大鼠实验性自身免疫性心肌炎模型（EAM模型），初步探讨心肌炎中血脂代谢紊乱可能的分子调节机制。 方法：利用猪心肌肌球蛋白和完全弗氏佐剂充分混合后，于第0天皮下注射建立大鼠EAM模型，留取心脏标本行组织切片H&E染色、心脏体重比、RealtimePCR、Westernblot评估心肌组织炎症程度；GPO-PAP法血脂试剂盒检测血脂水平；Filipin染色检测心肌组织内胆固醇水平 ...
戴东黎
core