Results 101 to 110 of about 1,550 (144)

苦参碱对小鼠坐骨神经损伤后脊髓运动神经元的影响

Zhongguo shiyan zhenduanxue, 2012
目的探讨BALB/c小鼠坐骨神经损伤后应用苦参碱后对坐骨神经相应脊髓节段中gap-43的表达变化。方法健康成年BALB/c小鼠320只,单侧坐骨神经切断吻合后,随机分组给药,不同时间获取L4-6脊髓节段,用Real time-PCR检测坐骨神经相应脊髓节段gap-43的表达变化,同时进行髓鞘LFB染色观察坐骨神经的恢复情况。结果 Real time-PCR结果显示高剂量和中剂量组12h,24h3d5d1w,2w,4w,gap-43表达量明显高于低剂量组和空白对照组,8w各组比较无明显差异 ...
曹剑, 王永安, 魏壮, 刘浩宇, 尹维田   +4 more
doaj  

[Underlying Mechanism of the circ_0011462/miRNA-1200/SP1 Axis in Regulating Inflammatory Response, Apoptosis, and Neural Regeneration in a Spinal Cord Injury Model]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Li M, Qin S, Ping W, Zhang C, Duan J, Li J.   +5 more
europepmc   +1 more source

水凝胶修复脊髓损伤作用机制的研究进展

Zhongshan Daxue xuebao. Yixue kexue ban
脊髓损伤（SCI）是一种病情重、预后差的中枢神经系统疾病，其所导致的严重的感觉、运动或自主神经功能障碍极大地降低了患者的生活质量。尽管SCI的治疗和护理方面已经取得了相当大的进展，但由于药物不能通过血脊髓屏障直接输送到SCI部位，且SCI后的局部微环境不利于植入干细胞的存活、分化和增殖，使SCI的临床疗效及预后并不令人满意。水凝胶因其优异的机械性能、可塑性以及良好的生物相容性和生物降解性，可以作为装载干细胞或药物的递送系统，提供良好的环境并控制其释放，也可以作为生物支架，支持和引导轴突再生 ...
杨溢珂, 任亚锋
doaj  

[Kahweol improves motor function of mice with spinal cord injury by inhibiting microglial activation <i>via</i> regulating the IκBα/NF-κB pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Xia J, Chen Y, Ren L, Li J, Song X, Tao L, Hu J.   +6 more
europepmc   +1 more source

[Effect of removing microglia from spinal cord on nerve repair after spinal cord injury in mice]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Jiang Q, Qi C, Sun Y, Xue S, Wei X, Fu H.   +5 more
europepmc   +1 more source

[Effects of mild hypothermia on neurological function in rats with spinal cord injury based on adenosine monophosphate activated protein kinase/Nod-like receptor protein 3 pathway]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Pan J, Yang Z.
europepmc   +1 more source

[Orexin-A promotes motor function recovery of rats with spinal cord injury by regulating ionotropic glutamate receptors]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
He G, Chu W, Li Y, Sheng X, Luo H, Xu A, Bian M, Zhang H, Wang M, Zheng C.   +9 more
europepmc   +1 more source

[Monotropein improves motor function of mice with spinal cord injury by inhibiting the PI3K/AKT signaling pathway to suppress neuronal apoptosis]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Chen Y, Xiao L, Ren L, Song X, Li J, Hu J.   +5 more
europepmc   +1 more source

[Experimental study of M2 microglia transplantation promoting spinal cord injury repair in mice]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Zhang J, Zhang X, Jiang Q, Qu D, Hu Y, Qi C, Fu H.   +6 more
europepmc   +1 more source

[Experimental study of endothelial progenitor cells derived small extracellular vesicles for spinal cord injury repair in mice]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2021
Lin J, Huang T, Gao T, Zheng X.
europepmc   +1 more source