miR-210 inhibitor对大鼠背脊髓神经元细胞氧化 应激的保护作用
摘 要:【目的】 观察miR-210 inhibitor对大鼠背脊髓神经元细胞氧化应激的保护作用?【方法】 体外培养大鼠背脊髓神经元细胞,随机分成正常组,H2O2组,H2O2联合miRNA Negative control组以及H2O2联合miR-210 inhibitor组?采用MTT法检测细胞的存活率,流式细胞仪检测细胞的凋亡率,活性氧检测试剂盒检测细胞内活性氧,Elisa检测NOX2?【结果】 qPCR结果显示,100 μmol/L H2O2处理可导致大鼠背脊髓神经元细胞内miR ...
doaj
[Linarin inhibits microglia activation-mediated neuroinflammation and neuronal apoptosis in mouse spinal cord injury by inhibiting the TLR4/NF-κB pathway]. [PDF]
Xiao L +8 more
europepmc +1 more source
[Jisuikang formula promotes spinal cord injury repair in rats by activating the YAP/PKM2 signaling axis in astrocytes]. [PDF]
Man H +7 more
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慢性压迫性颈髓损伤体感诱发电位变化与神经丝磷酸化异常的病理机制
【目的】 观察慢性压迫性颈脊髓损伤神经元和轴突中神经丝高度磷酸化和异常积聚的特征,探讨其介导体感诱发电位(SEP)变化的神经病理机制。【方法】 将20只SD大鼠随机分为实验组(n=15)和对照组(n=5),实验组采用聚氨酯胶片建立脊髓背侧慢性压迫模型;BBB评分法和SEP评估造模前、后6个月脊髓功能变化;Luxol Fast Blue(LFB)染色观察脱髓鞘变性、免疫组织化学法观察磷酸化(SMI-31)和非磷酸化(SMI-32)神经丝在脊髓灰质前角神经元、轴突中的表达,并探讨其与SEP变化的关系。【结果】
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[Therapeutic mechanism of basic fibroblast growth factor on spinal cord injury in rats based on the Notch/signal transducer and activator of transcription 3 signaling pathway]. [PDF]
Cao C +6 more
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[Study on vascular remodeling, inflammatory response, and their correlations in acute spinal cord injury in rats]. [PDF]
Xu Z, Xu W, Chen X, Zhou Y.
europepmc +1 more source
[Experimental study of tetramethylpyrazine-loaded electroconductive hydrogel on angiogenesis and neuroprotection after spinal cord injury]. [PDF]
Deng B +8 more
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[Eccentric kyphotic distraction reduction technique for treatment of lower cervical dislocation with locked facet joints]. [PDF]
Li Y +6 more
europepmc +1 more source
[Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator]. [PDF]
Shen X +6 more
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