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炎症、免疫与脑血管病的研究进展 [PDF]

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2021
炎症和免疫是脑血管病病理生理的重要部分,其动态变化影响着脑血管病的进程和预后。缺血性卒中急性期的炎症激活造成大脑病灶的炎症损伤,还参与衰老相关的脑小血管病的脑损害,引起血管性痴呆等认知功能障碍。本文就炎症和免疫与脑血管病相互作用机制的研究进展进行综述,以更好地了解和探索免疫调节在治疗中的潜力。
陆正齐
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HTRA1基因杂合突变相关遗传性脑小血管病1例并文献复习 Heterozygous HTRA1-related Hereditary Cerebral Small Vessel Disease: A Case Report and Literature Review

open access: yesZhongguo cuzhong zazhi, 2023
本文对1例60岁男性轻度认知障碍、头晕患者的临床症状、影像学和基因检测结果进行分析。该患者既往有高血压、高脂血症、高尿酸血症病史,以及长期吸烟、饮酒史,其母亲曾患痴呆,头颅MRI示多发腔隙性脑梗死、脑白质变性和多发微出血病灶,基因检测报告示HTRA1基因c.1174T>C杂合突变,以上结果符合HTRA1基因杂合突变相关遗传性脑小血管病的诊断。 Abstract: Clinical symptoms, imaging findings, and genetic testing results of ...
祖煜,于莎莎,张玉婧,吕晶,冯雪丹
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伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病患者大脑中动脉闭塞血管内治疗1例并文献复习 Endovascular Treatment of Middle Cerebral Artery Occlusion in Patient with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: A Case Report and Literature Review

open access: yesZhongguo cuzhong zazhi
伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)是NOTCH3基因突变所致的遗传性脑小血管病,主要病变血管为颅内小动脉,累及大脑皮质和颅内大/中动脉的报道较罕见,目前缺乏特效治疗方法。本文报道1例大脑中动脉急性闭塞成功接受血管内治疗的CADASIL病例,并结合文献进行讨论 ...
刘昱君,刘雷媛,徐炳东,韩建邦,杨冰,丁燕,杨英,孟珩,张玉生 (LIU Yujun, LIU Leiyuan, XU Bingdong, HAN Jianbang, YANG Bing, DING Yan, YANG Ying, MENG Heng, ZHANG Yusheng )
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不同神经心理症状与脑小血管病影像学关系的研究进展 Research Progress on the Relationship between Various Neuropsychological Symptoms and Imaging of Cerebral Small Vessel Disease

open access: yesZhongguo cuzhong zazhi
脑小血管病(cerebral small vessel disease,CSVD)是由各种病因影响脑内小血管所导致的一系列临床、影像、病理学综合征,其在国际上尚无统一诊断标准,症状轻微,故临床上主要根据神经影像学表现分为新近皮质下小梗死、假定血管源性腔隙、假定血管源性脑白质高信号、血管周围间隙、脑微出血、脑皮质表面铁沉积和脑萎缩。证据表明,CSVD可能与诸多神经心理学症状相关,然而,神经心理症状与CSVD发生和发展之间的关系目前尚不明确。本文对情感淡漠、疲劳、焦虑 ...
胡琨1,管玲2,3,王伊龙2,3,4,5,6,7,8 (HU Kun1, GUAN Ling2,3, WANG Yilong2,3,4,5,6,7,8 )
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Research progress on the relationship between white matter hyperintensity and cognitive impairment [PDF]

open access: yes, 2023
White matter hyperintensity (WMH) is one of the imaging markers of cerebral small vessel disease (CSVD). Recent studies have found certain relationship between WMH and cognitive impairment.
Zhao Dan, Lü Yan, Zhao Zhongyan, Wu Chanji, Xu Ruyan, Huang Shixiong
core   +1 more source

Cardiovascular health and brain aging : a population-based MRI study [PDF]

open access: yes, 2023
Deterioration of brain structure and cognitive function occurs as individuals reach advanced age. The former can be observed through various markers of cerebral small vessel disease on magnetic resonance imaging (MRI) scans and the later can be ...
Li, Yuanjing
core   +1 more source

大脑淋巴瘤病的临床及MRI特点分析 [PDF]

open access: yes, 2021
目的大脑淋巴瘤病(LC)是中枢神经系统淋巴瘤(PCNSL)的特殊类型,目前报道较少,预后较其它类型的PCNSL差,早期诊断对判断预后十分重要。本文报道经脑立体定向活检明确病理的大脑淋巴瘤病3例,以提高临床医师对大脑淋巴瘤病的认识。方法回顾性分析2017年1月-2020年7月间,中山大学附属第三医院岭南医院确诊为大脑淋巴瘤病3例患者的临床表现、影像学、神经病理特征。结果3例患者分别为44、61和64岁男性,出现进展性认知下降、视物模糊、下肢乏力等神经功能障碍表现,脑部核磁共振(MRI ...
卢德宏   +7 more
core   +1 more source

The Glymphatic System:a New Exploration of Pathological Mechanism in Stroke [PDF]

open access: yes, 2022
The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel ...
YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin
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脑小血管病脑白质损伤动物模型 Animal Models of Cerebral Small Vessel Disease with White Matter Lesion

open access: yesZhongguo cuzhong zazhi, 2019
【摘要】 脑小血管病是导致认知功能减退、步态情感障碍和痴呆的重要脑血管疾病,脑白质弥漫性损伤是该病的重要影像学特征。结合国内外近年来相关研究内容,本文对不同的脑小血管病白质损伤动物模型制作进行了系统性回顾,包括单一型动物模型如双侧颈总动脉狭窄模型、脑淀粉样血管病模型、Notch3转基因小鼠模型、自发性高血压大鼠模型、易卒中型肾血管性高血压大鼠模型,以及由两个或两个以上单一型动物模型组合而成的复合型动物模型等。 【Abstract】 In recent years, cerebral small ...
董成亚,王伊龙,刘向荣
doaj   +1 more source

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