Results 21 to 30 of about 5,664 (144)
脑小血管病与步态障碍相关性研究进展 Advance in Gait Disorder in Cerebral Small Vessel Disease
Zhongguo cuzhong zazhi, 2018 脑小血管病的影像改变包括脑白质高信号、腔隙性脑梗死、血管周围间隙、脑微出血、脑 萎缩等。步态障碍是脑小血管病的重要临床特征，进一步导致跌倒风险增加。脑小血管病破坏脊髓 运动系统和皮层、基底节纤维联系的完整性，同时存在视空间和执行功能障碍、抑郁状态等多种认 知或精神心理障碍，均与步态异常显著相关。在步态障碍的上述产生机制中，侧脑室周围、额叶深部 白质疏松与运动协调和认知损伤相关；腔隙性脑梗死常见于运动-认知风险人群；血管周围间隙、一 定数量的脑微出血、脑萎缩或脑灌注异常等均会导致认知损伤相关步态障碍 ...
柴湘婷，王祥翔，张瑞霞，马玲丽，谭兰
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The role of atrial fibrillation in cognitive aging : a population-based study [PDF]
, 2019 The role of atrial fibrillation (AF) in brain and cognitive aging (e.g., cognitive decline and dementia) is still unclear. In this doctoral thesis, we aimed to investigate the temporal trends and potential determinants of dementia incidence, the ...
Ding, Mozhu
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卒中后认知障碍临床诊疗实践面临的挑战 Challenges in Clinical Practice of Post-Stroke Cognitive Impairment
, 2023 卒中后认知障碍（post-stroke cognitive impairment，PSCI）是指在卒中事件后6个月内发生的任何程度的认知损害。因为卒中患者常出现失语、失用和失认，所以PSCI的神经心理学评估不同于一般的成套评估，需要选取合适的测验，否则容易高估患者的认知损害程度。PSCI病因具有复杂性，需要全面考虑，除了卒中的病因之外，还需要考虑与脑储备相关的脑病理背景，如脑小血管病和神经系统变性病。对于PSCI的治疗，病因及对症治疗、药物和非药物治疗都很重要。 Abstract: Post ...
刘彩燕，程安琪，徐蔚海
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Construction of a predictive model for cerebral small vessel disease MRI burden based on β2-microglobulin and lipoprotein(a) [PDF]
Objective To construct a predictive model for cerebral small vessel disease (CSVD) MRI burden based on β2-microglobulin (β2-MG) and lipoprotein(a) [Lp(a)], analyze its predictive value, and validate the model. MethodsA total of 138 CSVD patients admitted
Bin LI +6 more
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, 2020 【目的】对比阿尔茨海默病（AD）和血管性痴呆（VaD）的脑区体积及脑白质高信号（WMH）差异，并探究 MRI 对 AD 与 VaD 的鉴别诊断价值。【方法】回顾性分析 35 例 VaD 和 74 例 AD 患者的临床资料和 MRI 影像资料。利用AccuBrainTM 提取不同脑区及WMH 的体积测量值，并利用视觉评分量表评估所有患者WMH；比较AD与VaD 脑区体积及WMH 差异，鉴别诊断采用主成分分析（PCA）和logistic 回归模型两种方法，最后评价各指标的诊断效能。【结果】①AD ...
吕发金 +5 more
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血管超声在脑小血管病中的应用进展 Application Progress of Vascular Ultrasound in Cerebral Small Vessel Disease
Zhongguo cuzhong zazhi超声由于其独特的优势已逐渐应用于脑小血管病领域。本文汇总了超声在脑小血管病中应用的相关研究，概述了脑小血管病与血管超声各类评估指标之间的关系，并描述了超声在与脑小血管病并存的心、脑、肾等多系统疾病中的评估、诊断作用，为应用超声对脑小血管病进行全面有效评估提供了理论依据。 Abstract: Ultrasound has been gradually applied to the field of cerebral small vessel disease (CSVD) due to its ...
潘希娟，邢英琦，刘玉梅 (PAN Xijuan, XING Yingqi, LIU Yumei)
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Zhongguo cuzhong zazhi, 2023 脑小血管病（small vessel disease,SVD）是衰老过程中的常见疾病，可出现卒中、认知障碍、神经心理症状或其他功能损害表现。脑小血管病国际影像标准1（standards for reporting vascular changes on neuroimaging 1，STRIVE-1）对结构MRI上所见的SVD不同影像特征，包括脑白质高信号、血管周围间隙、微出血、近期皮质下小梗死、假定血管源性腔隙和脑萎缩，进行了分类和标准化。随着对SVD影像特征认识的逐渐清晰，以及机器学习方法的迅速兴起，
叶瑾怡1*，王赞1*，龚宇田1，郭蕾1，果彤1，胡琨1，陆瑶1，单舒乙1，王玲1，悦芳芳1，朱婧涵1，郑欣雅1，陈玮琪1，2，王伊龙1，2，3，4，5，6，7（*第一作者）
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Research progress on the role and mechanism of the glymphatic system in the occurrence and development of brain diseases [PDF]
Biomedical research in recent years has revealed a new mechanism by which the brain can effectively remove metabolic waste generated by the neural tissue through the glymphatic system.
CHANG Junlei, FENG Ziying
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H-type hypertension: a key point for primary stroke prevention in China [PDF]
H-type hypertension is accompanied by elevated homocysteine （Hcy） （≥10 μmol/L） in the blood， which synergistically increases the risk of cardiovascular diseases with hypertension， especially stroke. Approximately 75% of hypertensive patients in China are
Fan Fangfang, Huo Yong
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, 2023 脑小血管病（cerebral small vessel disease，CSVD）发病率高，病因复杂，精确诊断、分类和随访较为困难。目前，CSVD基因组学已发现超过50个独立遗传位点与CSVD发病风险相关，涉及细胞外基质组成、髓鞘形成、膜转运等病理生理机制，且与临床表现相关。转录组学发现多种微小RNA在CSVD痴呆患者和健康对照中差异性表达；蛋白组学研究异质性较大，提示需选用蛋白质标志物的特定组合才可能有助于CSVD的诊断和分型；宿主-微生物组学研究提示CSVD存在肠道-免疫-脑轴的致病机制 ...
陈悦薇, 徐群
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