目的: 研究小檗碱( Ber)对原代培养的大鼠大脑皮质和小脑颗粒神经元的直接作用及 Ber 与间接胆红素的相互 作用。方法: 采用二乙酸荧光素( FDA)和 Hoechst 33258 DNA 染色法,观察神经元的存活率及形态学特征; 用琼脂糖凝胶电泳 和流式细胞仪分析 Ber 诱导神经元死亡的生化学特征。结果: Ber 呈剂量( 0~ 20μmol/L)依赖性地诱导原代培养的大鼠大脑 皮质和小脑颗粒神经元死亡。其死亡的机制呈现坏死的特征: 包括神经元胞体肿大、无明显核染色质浓缩、DNA 随机断裂而 ...
doaj
[Neural mechanisms of fear responses to emotional stimuli: a preliminary study combining early posterior negativity and electroencephalogram source network analysis]. [PDF]
Zang Q, Zhao X, Liang T, Liu X, Lou C.
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[A study on the effects of transcranial direct current stimulation combined with motor imagery on brain function based on electroencephalogram and near infrared spectrum]. [PDF]
Yao H, Yu H, Du B.
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[Development and electrophysiological validation of a temporal interference transcranial magnetic stimulation system for mice]. [PDF]
Cui C, Wang T, Zhang Y, Zheng W, Xu G.
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用膜片钳技术,在新生大鼠大脑皮层完整神经元膜上记录了电导为35pS的N-甲基-D-门冬氨酶(NMDA)通道电流并在无Mg2+条件下,详细分析了通道动力学的电压依赖性。NMDA通道对Na+、K+非选择性通透,对Cl-不通透,APV能阻断通道活动。通道的开放时间、burst时程及开放概率随超极化程度增大而减小。开放时间和burst时程的分布直方图均需双指教拟合,它们的慢时间成分也显示相似的电压依赖性。结果表明:完整神经元NMDA受体自身的通道动力学有明显的电压依赖性。
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[A case of Harel-Yoon syndrome with seizures caused by an ATAD3A variant]. [PDF]
Yang Q, Pan Z, Chen C, Yin F, Peng J.
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[Resveratrol protects barrier function of mouse brain microvascular endothelial cell monolayers with oxygen/glucose deprivation and PM<sub>2.5</sub> exposure by maintaining mitochondrial dynamics balance]. [PDF]
Qin M +9 more
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[Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats]. [PDF]
Liu S, Wang L, Li S, Xu G.
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[Brain-controlled unmanned aerial vehicle system based on meta brain computer interface open-source software platform]. [PDF]
Li A +5 more
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