Chinese Social Media Reaction to Information about 42 Notifiable Infectious Diseases [PDF]
This study aimed to identify what information triggered social media users' responses regarding infectious diseases. Chinese microblogs in 2012 regarding 42 infectious diseases were obtained through a keyword search in the Weiboscope database ...
Cai, J +7 more
core +3 more sources
American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non–Small-Cell Lung Cancer [PDF]
The purpose of this article is to provide updated recommendations for the treatment of patients with stage IV non-small-cell lung cancer. A literature search identified relevant randomized trials published since 2002.
AZZOLI, Christopher G +21 more
core +1 more source
Abstract Background Antiangiogenesis tyrosine kinase inhibitors (TKIs) have been shown to prolong progression‐free survival (PFS) in advanced osteosarcoma. Methylsulfonic apatinib is a TKI that specifically inhibits vascular endothelial growth factor receptor‐2.
Lu Xie +6 more
wiley +1 more source
Arsenic Trioxide Induces T cell Apoptosis and Prolongs Islet Allograft Survival in Mice [PDF]
目的:作为一种最有潜力的I型糖尿病的治疗方法,胰岛移植目前已经应用于临床。然而,免疫因素特别是T细胞介导的移植物活性损伤与功能丧失是胰岛移植应用的一大障碍。一直以来,科学家们都在寻找适用于胰岛移植的新型免疫抑制剂。三氧化二砷是临床上治疗早幼粒细胞白血病的特效药,最近被证明能够抑制同种异体心脏移植排斥反应。在此基础上,本文研究了三氧化二砷对同种异体胰岛移植免疫排斥的抑制作用,以及三氧化二砷与雷帕霉素联合诱导免疫耐受的可能作用机制。 方法:我们首先检测了三氧化二砷对胰岛细胞的毒性作用 ...
高畅
core +1 more source
应用Illumina MiSeq测序技术对腹泻北平顶猴肠道菌群的分析
为探寻可能导致北平顶猴(Macaca leonina)腹泻的菌群及其变化规律,分别采集6只健康和6只腹泻北平顶猴的新鲜粪便,应用Illumina MiSeq高通量测序技术测定其肠道菌群的结构以及腹泻过程中肠道菌群的动态变化。结果表明:健康组肠道菌群的Shannon指数(P=0015)、Chao 1指数(P=0014)、ACE指数(P=0032)较腹泻组高。在门水平上,腹泻组肠道中拟杆菌门(Bacteroidetes)、变形菌门(Proteobacteria)和未鉴定细菌(unidentified ...
金洁 1 +5 more
doaj
NF-κB、25-(OH)D3、CK-MB在儿童病毒性腹泻中的表达及临床意义
病毒性腹泻属于感染性腹泻的一种,由病毒感染所致,其临床症状多表现为呕吐、排便次数增多、机体水电解质紊乱等,其中以轮状病毒(Rotavirus,RV)感染性腹泻最为常见,另外因儿童各器官功能与成人相比尚未发育成熟,免疫功能低下,加之消化系统酶系活性较低、消化液分泌不足,较易受到病毒入侵,最终导致病毒性腹泻的发生[1-3]。
孟祥会, 陈营, 董旭
doaj
On the Generation of Medical Question-Answer Pairs
Question answering (QA) has achieved promising progress recently. However, answering a question in real-world scenarios like the medical domain is still challenging, due to the requirement of external knowledge and the insufficient quantity of high ...
Du, Nan +9 more
core +1 more source
Investigation of the in vitro and in vivo protective activity of antibody against rotavirus inner capsid protein VP6 [PDF]
轮状病毒(Rotavirus)是全球范围内引起婴幼儿腹泻的主要病原体之一,每年导致40-60万死亡病例和超过200万住院病例,造成严重的社会经济负担。安全有效的疫苗是控制轮状病毒的重要手段,目前已经有3种减毒活疫苗上市,并且在欧美等国具有较高的安全性和有效性。但是,这些疫苗在轮状病毒导致死亡率较高的非洲和亚洲地区有效性较低,且会增加患肠套叠的风险,存在一定的安全问题。因此,更加高效、安全的基因工程疫苗的研究已经成为轮状病毒疫苗研究的主要方向。 研究表明 ...
俞林岐
core
Clinical Observation of Erlotinib in the Treatment of Advanced Non-small Cell Lung Cancer: A Report of 92 Eases [PDF]
Background and objective Erlotinib, a selective inhibitor of epidermal growth factor receptor tyrosine kinase, has been approved effective in local advanced or metastatic non-small cell lung cancer (NSCLC).
Aiqin GU +5 more
core
Study on disinfection and sterilization of high algae-laden water with Hydroxyl radicals [PDF]
消毒灭菌是饮用水处理工艺中的重要组成部分。而地表水富营养化现象日益加剧,导致水源地高藻频发,增加了饮用水常规氯消毒处理工艺的负担,严重威胁城市供水卫生安全。如何平衡饮用水微生物安全性与化学安全性,成为当前高藻饮用水消毒技术研究的重要内容。本文依托国家科技支撑计划项目“高藻水源地供水卫生保障羟基自由基氧化技术研发与示范”(NO.2013BAC06B00),针对厦门市重要水源地九龙江北溪流域水体,通过大气压强电离放电规模制备羟基自由基(•OH),建立了高藻饮用水•OH消毒灭菌处理工艺,
黄孟斌
core

