膀胱癌抑癌基因Apaf-1和APC的甲基化状况 及其临床意义
【目的】 研究抑癌基因细胞凋亡蛋白酶活化因子-1(Apaf-1)和腺瘤性结肠息肉病相关基因(APC)的启动子甲基化状况与膀胱癌临床病理的关系及对患者复发的影响65377;【方法】采用甲基化特异性PCR方法检测110例膀胱癌组织中Apaf-1和APC的启动子甲基化状态,以15例正常膀胱黏膜组织为对照组65377;【结果】 Apaf-1和APC基因在膀胱癌组织中的甲基化率为90.0%和82.7%,在正常膀胱组织为6.77%和20.0%,差异分别有统计学意义(P均 = 0.000)65377;Apaf ...
doaj
O-GlcNAcylated YTHDF2 promotes bladder cancer progression by regulating the tumor suppressor gene <i>PER1</i> via m<sup>6</sup>A modification. [PDF]
Wang L +5 more
europepmc +1 more source
miR-101-3p与膀胱癌细胞增殖、迁移、侵袭和顺铂敏感性的关系研究
目的 探究miR-101-3p与膀胱癌细胞增殖、迁移、侵袭和顺铂敏感性的关系。方法 将膀胱癌细胞分为对照组、下、上调miR-101-3p组,体外培养膀胱癌细胞。采用CCK-8实验来检测膀胱癌细胞增殖能力;通过划痕实验来检测膀胱癌细胞迁移能力;通过Transwell实验来检测膀胱癌细胞侵袭能力;3组细胞分别加入不同浓度的顺铂,观察对细胞的抑制率;Western blot法测定CDK4、Akt、ICAM-1、MMP-9蛋白的表达量。结果 在24 h、48 h、72 h的细胞增殖率方面,上调miR-101 ...
崔伯阳 +5 more
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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment. [PDF]
Zeng S, Xing S, Zhang Y, Wang H, Liu Q.
europepmc +1 more source
[High expression of miR-204-5p promotes malignant behaviors of bladder cancer cells by negatively regulating RAB22A]. [PDF]
Li L +7 more
europepmc +1 more source
[A Randomized Controlled Study of Intravesical Instillation Therapy of Bacillus Calmette-Guérin vs. Epirubicinin Treating Non-muscular Invasive Bladder Cancer]. [PDF]
Yang WX +5 more
europepmc +1 more source
[Prognostic factors of patients with muscle invasive bladder cancer with intermediate-to-high risk prostate cancer]. [PDF]
Ou J +10 more
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[Bladder cancer local staging about muscle invasion: 3.0T MRI performance following transurethral resection]. [PDF]
Zhao SM +7 more
europepmc +1 more source
目的: 探讨无创早期诊断膀胱癌的有效方法: 对膀胱癌患者进行尿液中膀胱肿瘤抗原( BTA)测定与分析。方法: 对 64 例膀胱癌及 28 例非膀胱癌患者的尿进行 BTA 测定及尿脱落细胞学检查, 比较这两种方法的敏感度、特异度、准确度、阳 性及阴性似然比。结果: BTA 测定的敏感度、准确度、特异度、阳性及阴性似然比分别为 90. 6%、89. 3%、90. 2%、8. 5 及 0. 1; 尿脱落细胞学检查这些指标分别为 46. 9%、92. 9%、60. 9%、6. 6 及 0.
doaj
[A pan-cancer analysis of PYCR1 and its predictive value for chemotherapy and immunotherapy responses in bladder cancer]. [PDF]
Li Y, Song X, Sun R, Dong X, Liu H.
europepmc +1 more source

