Results 11 to 20 of about 2,369 (100)
Journal of Traumatic Stress, Volume 35, Issue 2, Page 581-592, April 2022., 2022 Abstract Pakistan is considered to be relatively unsafe for journalists; however, little is known about how working in situations that involve a high risk of trauma exposure and personal threat impacts journalists’ mental health. The present study aimed to examine the associations among reporting on topics that carry a high risk of trauma exposure ...
Suzanna M. Koster +3 more
wiley +1 more source
Journal of Applied Ecology, Volume 58, Issue 11, Page 2566-2578, November 2021., 2021 The development of fungicide resistance greatly threatens food security and ecological sustainability, and it is urgent need to develop agricultural practices which can ameliorate this problem. Our results show that potato crop with a genetic diversity is associated with a late blight pathogen of higher fungicide sensitivity and lower potential of ...
Li‐Na Yang +8 more
wiley +1 more source
Detecting deterrence from patrol data
Conservation Biology, Volume 33, Issue 3, Page 665-675, June 2019., 2019 Abstract The threat posed to protected areas by the illegal killing of wildlife is countered principally by ranger patrols that aim to detect and deter potential offenders. Deterring poaching is a fundamental conservation objective, but its achievement is difficult to identify, especially when the prime source of information comes in the form of the ...
Andrew D. M. Dobson +4 more
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 2, Page 148-158, April 2025.Background – Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.
Bhumika F. Savaliya +3 more
wiley +1 more source
Wildlife Letters, Volume 2, Issue 4, Page 179-191, December 2024.We identified seven groups reflecting different patterns of engagement with wildlife, ranging from Champions to Disengaged. Outdoor recreation had the most consistent pattern of association with group membership. Respondents who were members of more engaged groups were also more likely to exhibit polarized views about wildlife management strategies ...
Cristina Romero‐de‐Diego +3 more
wiley +1 more source
Study on the targeted therapy for colorectal cancer in vivo with CD-TK driven by CEA promoter [PDF]
, 2010 研究背景 大肠癌是严重威胁人类健康的常见恶性肿瘤之一，目前在我国大城市已占恶性肿瘤发病率的第三位。尽管随着疾病的早期发现、手术方案的改进以及新的化疗药物的应用，患者的中位生存期较前有了很大的提高，但要达到长期无瘤生存还是很大的难题。因此，寻求新的有效的治疗手段成为目前亟需解决的问题。随着分子生物学和基因工程技术的不断发展，肿瘤的自杀基因疗法成为当今的研究热点。目前，CD-TK双自杀基因在相关的研究报道中初步显示了较好的抗肿瘤疗效 ...
孟敏君
core
Sexuality, Gender &Policy, Volume 7, Issue 4, Page 366-381, November 2024.Abstract This paper is based on a study funded by the National Office for Suicide Prevention (NOSP), exploring sex worker mental health through a qualitative study of eighteen sex workers living and working in the Republic of Ireland and with participants from service provider organizations. This paper utilizes and adapts the concept of minority stress
Paul Ryan +3 more
wiley +1 more source
The Construction of Targeted Gene Therapy Vector and Its Cytoxicity on The Colorectal Carcinoma Cells [PDF]
, 2009 目的: 构建由癌胚抗原启动子(CEApromoter，Cp)驱动的双自杀基因CD-TK治疗载体pcDNA3.1(-)Cp-CD-TK，研究癌胚抗原启动子能否控制CD-TK基因在CEA阳性大肠癌细胞中专一性表达和杀伤，比较融合基因与单基因对肿瘤细胞生长抑制方面有无差异，是否存在协同效应，并确定安全有效的药物使用浓度。观察旁观者效应。 方法: 分别以提取的人血细胞基因组DNA，pMD18-CD质粒和tgCMV/Hy-TK质粒为模板，PCR扩增Cp、CD和TK基因片段，采用双酶切、连接等方法依次将Cp、CD ...
黄琳
core
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
放疗增强对转染pAdKDR/CD/TK自杀基因系统的SW480大肠癌细胞的杀伤作用
Zhongguo shiyan zhenduanxue, 2013 目的研究γ射线照射对含KDR启动子双自杀基因大肠癌细胞SW480的杀伤协同作用,和自杀基因及前药的放射增敏作用。方法重组腺病毒pAdKDR-TK、pAdKDR-CD和pAdKDR-TK/CD转染SW480细胞,观察γ射线对SW480细胞基因转染率的增强作用和对前药GCV、5-FC、GCV+5-FC杀伤SW480细胞的放射增敏效应,以及前药GCV、5-FC、GCV+5-FC对γ射线杀伤SW480细胞的协同增效作用。结果转染双自杀基因的大肠癌细胞射线组比对照组转染率有明显升高 ...
刘志毅, 金虎, 翟春亮, 刘明
doaj