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抗体药物偶联物治疗转移性去势抵抗性前列腺癌研究进展 [PDF]
浙江大学学报. 医学版转移性去势抵抗性前列腺癌（mCRPC）患者因肿瘤异质性和耐药性预后不佳，抗体药物偶联物（ADC）治疗mCRPC部分临床试验中已展现出抗肿瘤活性及较好的安全性。在靶向前列腺特异性膜抗原（PSMA）的ADC中，相较于早期ADC如MLN2704、PSMA-ADC、MEDI3726，ARX517安全性更优，前列腺特异性抗原下降更显著。在靶向B7-H3的ADC中，MGC018和DB-1311也展现出抗肿瘤活性。靶向前列腺六跨膜上皮抗原（STEAP）1的DSTP3086S、靶向滋养层细胞表面抗原（TROP ...
徐 嘉程 +5 more
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Research progress in the role of gut microbiota in the pathogenesis and treatment of IgA nephropathy [PDF]
, 2023 As the most common form of glomerulonephritis worldwide, IgA nephropathy (IgAN) is characterized by the diffuse deposition of immune complexes formed by glycosylation-deficient IgA1 (Gd-IgA1) and its specific antibodies (Gd-IgA1-IgG) in the glomerular ...
LI Junru, OUYANG Yan, XIE Jingyuan
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Evaluation of adverse events of CDK4/6 inhibitors: a real-world study based on the FAERS database [PDF]
, 2023 Background and purpose: The development and approval of inhibitors of cyclin-dependent kinase 4/6 (CDK4/6) is an essential milestone in treating hormone receptor-positive metastatic breast cancer.
SHE Youjun, GUO Zihan, ZHANG Zhongwei, DU Qiong
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Guidelines for breast cancer diagnosis and treatment by China Anti-cancer Association (2024 edition) [PDF]
, 2023 According to the latest data released by the International Agency for Research on Cancer of the World Health Organization (WHO), breast cancer has become the malignant tumor with the highest incidence rate around the world, seriously endangering the ...
The Society of Breast Cancer China Anti-Cancer Association, Breast Oncology Group of the Oncology Branch of the Chinese Medical Association
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Evaluation of medication treatment for Alzheimer's disease on clinical evidence [PDF]
, 2014 Objective To formulate the best treatment plan for Alzheimer's disease patients by evaluating the therapeutic efficacy and side effect of various evidence-based programs.
Ling LIU +3 more
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Research Progress on the Molecular Mechanisms of Toxicology of Ethanol-Aconitine Induced Arrhythmia [PDF]
, 2020 Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well.
PAN Mei-chen, ZHOU Xiao-wei, LIU Yan,et al.
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Research Progress on the Synthesis and Bioactivities of Indole-3-glyoxylamide Derivatives [PDF]
, 2017 综述了吲哚-3-乙醛酰胺类化合物(ID)的合成及生物活性的研究进展。ID具有抗肿瘤、抗病毒、抗菌、抗炎、腺苷受体功能调节、缓解疼痛和抗类风湿关节; 炎等多种生物活性,在药物化学领域有广泛应用。ID的合成方法主要为:吲哚母核与乙酰氯在乙醚(或THF)中于室温反应1; h制得含草酰氯结构的中间体;中间体与取代胺基化合物和二异丙基胺乙基胺反应合成ID。并对ID未来的应用作了简要展望。The synthesis and bioactivities of indole-3-glyoxylamide ...
方美娟, 王飞, 胡鸿雨, 赵胜贤
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Zhongguo shiyan zhenduanxue, 2022 目的 分析碳青霉烯耐药肺炎克雷伯菌的耐药表型和基因型等特征，为临床抗感染治疗提供实验依据。方法 收集2017年5月至2021年4月间住院患者感染性标本中分离的碳青霉烯耐药肺炎克雷伯菌，采用VITEK-2compact全自动细菌鉴定/药敏分析系统对碳青霉烯耐药菌株进行鉴定和药敏试验，应用SPSS Statistics 17.0软件进行耐药率差异分析。结果 共获得碳青霉烯耐药肺炎克雷伯菌55株，耐药菌株来源于痰液标本31株、尿液标本14株、血液标本10株；药敏结果显示 ...
孙胜君, 张昌莲, 赵自云
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Zhongguo shiyan zhenduanxue, 2022 目的 探索外泌体来源的miR-21作为胃癌奥沙利铂化疗过程中评价药物敏感性生物标志物的价值。方法透射电镜观察外泌体的形态；构建SGC7901奥沙利铂耐药细胞株，并利用RT-qPCR检测耐药细胞和亲本细胞中miR-21的表达水平；CCK8检测miR-21对SGC7901耐药细胞株增殖抑制率的影响；Western blot检测外泌体的标记蛋白；使用受试者工作特征曲线（ROC）分析奥沙利铂治疗胃癌的过程中miR-21评估药物敏感性的价值。结果miR-21过表达后，亲本细胞对奥沙利铂的敏感性由IC50 16 ...
杜沛, 李婷, 文雯
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Zhongguo shiyan zhenduanxue, 2021 目的 建立人胃癌耐药细胞,为研究人胃癌耐药细胞的耐药机制以及为耐药肿瘤细胞的治疗提供耐药肿瘤细胞模型。方法 体外培养人胃癌细胞SGC-7901,用50μmol/L顺铂多次反复冲击,对冲击4次和6次的SGC-7901分别检测对顺铂的抑制率和多药耐药基因（MDR）及多药耐药特异基因片段的表达,并计算药物对细胞的半数抑制浓度（IC50）。结果 经4次和6次冲击后,受冲击的SGC-7901胃癌细胞对顺铂的抑制率明显高于亲本细胞,IC50为63.98μmol/L和66.34μmol/L,而亲本细胞SGC ...
刘玉侠 +6 more
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