Results 1 to 10 of about 3,855,809 (165)

SARS‐CoV‐2 infection as cause of in‐utero fetal death: regional multicenter cohort study

Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 6, Page 867-874, December 2023., 2023
ABSTRACT Objective Placental infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to placental insufficiency and in‐utero fetal death (IUFD). The objective of this study was to confirm and quantify the extent to which fetoplacental infection with SARS‐CoV‐2 is a cause of fetal death.
M. Nkobetchou, M. Leruez‐Ville, T. Guilleminot, N. Roux, G. Petrilli, F. Guimiot, M.‐H. Saint‐Frison, I. Deryabin, Y. Ville, V. Faure‐Bardon   +9 more
wiley   +1 more source

Decreased in n‐3 DHA enriched triacylglycerol in small extracellular vesicles of diabetic patients with cardiac dysfunction 糖尿病合并心脏功能障碍患者细胞外小囊泡中n‐3 DHA 富集的三酰甘油减少

Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023
Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding, Xuejuan Zhang, Dandan Xiao, Wenguang Chang   +3 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels 韩国2型糖尿病患者谷氨酸升高与纤溶酶原水平升高有关

Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee, Jeong Won Yeom, Ji Ho Yun, Han Byul Jang, Min‐Gyu Yoo, Hyo‐Jin Kim, Soo Kyung Koo, Hye‐Ja Lee   +7 more
wiley   +1 more source

MsaH2A.W is identified response to salt tolerance in Miscanthus sacchariflorus

GCB Bioenergy, Volume 15, Issue 8, Page 1058-1073, August 2023., 2023
To study the underlying genetic basis of Miscanthus adaptation to salt stress, the transcriptome variations of Miscanthus sinensis, Miscanthus sacchariflorus and their hybrid were analysed using RNA‐seq technology under salt treatment. According to the expression pattern of known salt‐tolerant genes, a histone variant gene MsaH2AW of M.
Ting Yu, Yancui Wang, Pingping Xu, Senan Cheng, Xinwei Hou, Guofeng Geng, Zhiqiang Pan, Shukai Wang, Dusheng Lu, Shubo Gu, Xitong Xu, Zhixin Liu, Cuixia Chen   +12 more
wiley   +1 more source

Insights from basic adjunctive examinations of GCK‐MODY, HNF1A‐MODY, and type 2 diabetes: A systemic review and meta‐analysis GCK‐MODY、HNF1A‐MODY和2型糖尿病的基础辅助检查的见解:一项系统回顾和meta分析

Journal of Diabetes, Volume 15, Issue 6, Page 519-531, June 2023., 2023
Highlights For distinguishing glucokinase maturity‐onset diabetes of the young (GCK‐MODY) from hepatocyte nuclear factor 1‐α MODY (HNF1A‐MODY), total triglycerides may help during the follow‐up period. In order to discriminate GCK‐MODY from MODY‐like type 2 diabetes, high‐sensitivity C‐reactive protein may be a suitable indicator in the early stage ...
Jing Liu, Xinhua Xiao, Qian Zhang, Miao Yu   +3 more
wiley   +1 more source

Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology

Veterinary Dermatology, Volume 34, Issue 3, Page 175-208, June 2023., 2023
Abstract Background Allergic skin diseases are common in horses worldwide. The most common causes are insect bites and environmental allergens. Objectives To review the current literature and provide consensus on pathogenesis, diagnosis, treatment and prevention. Materials and Methods The authors reviewed the literature up to November 2022.
R. Marsella, S. White, V. A. Fadok, D. Wilson, R. Mueller, C. Outerbridge, W. Rosenkrantz   +6 more
wiley   +1 more source

Effect of sodium‐glucose cotransporter 2 inhibitors on the rate of decline in kidney function: A systematic review and meta‐analysis 钠‐葡萄糖共转运蛋白2抑制剂对肾功能下降速度的影响:系统综述和meta分析

Journal of Diabetes, Volume 15, Issue 1, Page 58-70, January 2023., 2023
Highlights Sodium/glucose cotransporter‐2 inhibitors (SGLT‐2i) showed an important renoprotective effect on sustained administration, regardless of the presence of diabetes, the baseline estimated glomerular filtration rate (eGFR) and different types of SGLT‐2i. There was an acute decline of eGFR in the initial administration (4.02 ml/min/1.73 m2), and
Yanbei Duo, Junxiang Gao, Tao Yuan, Weigang Zhao   +3 more
wiley   +1 more source

蛋白质组学在口腔疾病生物标记物中的应用

Zhongguo shiyan zhenduanxue, 2021
的强有力工具,基于质谱分析（mass spectrometric analysis,MS）可对一组基因表达的所有蛋白质进行鉴定和检测,结合生物信息学和数据库等工具,可深入探索疾病发生发展机制。本文检索了蛋白质组学相关最新技术,并就蛋白质组学在探索口腔疾病生物标记物中的应用进行综述,为疾病的早期诊断和预防提供参考。1蛋白组学的定义和技术蛋白质组学是1994年由Marc Wilkins首次提出,可对一组基因所表达的全部蛋白质进行分析检测,在功能基因组学的研究领域中作用显著 ...
高思宇, 吴佳, 谢元栋, 詹骆宁, 胡玲, 李毅   +5 more
doaj  

液质联用方法用于多发性硬化的血浆蛋白质组标志物研究

Zhongguo shiyan zhenduanxue, 2021
目的通过血浆蛋白质组液质联用分析寻找多发性硬化疾病中差异表达蛋白,寻找多发性硬化早期诊断相关的血浆标志物。方法选取多发性硬化患者和健康对照人各9例,采用10标TMT标记技术进行血浆蛋白质组分析,筛选差异蛋白。结果液质联用血浆蛋白质组差异分析共鉴定到52个差异蛋白质,其中上调27个,下调25个。差异蛋白质功能分析显示,这些蛋白与免疫系统、补体系统、急性期反应信号等通路相关。结论在血浆蛋白质组中可以找到与多发性硬化相关的蛋白质,这些有可能成为其早期诊断的标志物 ...
杨雯棋, 吴绍长, 周大金, 章丽娟, 闫秀梅, 何成彦, 何平, 孙景春, 赵龙友   +8 more
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