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靶向抑制生长分化因子3减轻内皮细胞炎症反应并抑制脉络膜新生血管

open access: yesZhongshan Daxue xuebao. Yixue kexue ban
目的揭示靶向抑制生长分化因子3(GDF3)对脉络膜新生血管(CNV)形成及内皮炎症反应的影响。方法构建激光诱导的小鼠CNV模型,通过RNA测序(RNA-seq)筛选差异基因。采用实时荧光定量PCR(RT-qPCR)和Western blot验证GDF3表达水平。通过siRNA及中和抗体拮抗内皮细胞GDF3,采用CCK8实验、划痕实验及成管实验评估内皮细胞增殖、迁移和血管生成能力。检测炎症/黏附分子表达变化,分析免疫细胞黏附和跨内皮迁移实验变化。在CNV模型中,通过玻璃体腔注射shRNA靶向抑制GDF3 ...
唐榕穗, 田壹, 熊振, 李旭日
doaj   +2 more sources

Identification of ceRNA networks in type H and L vascular endothelial cells through integrated bioinformatics methods. [PDF]

open access: yesZhong Nan Da Xue Xue Bao Yi Xue Ban
Liu Z   +7 more
europepmc   +1 more source

[PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics]. [PDF]

open access: yesNan Fang Yi Ke Da Xue Xue Bao
Yu J   +6 more
europepmc   +1 more source

Protective effects of areca nut polyphenols on hypoxic damage of rat pulmonary microvascular endothelial cells. [PDF]

open access: yesZhejiang Da Xue Xue Bao Yi Xue Ban, 2022
He J   +6 more
europepmc   +1 more source

[Application and challenges of tissue engineered scaffolds in treatment of long-segment laryngotracheal stenosis]. [PDF]

open access: yesZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Yu Q   +7 more
europepmc   +1 more source

[A case of segmental atrophy of the liver in children]. [PDF]

open access: yesZhonghua Gan Zang Bing Za Zhi
Qiu YL, Mao Y, Lu CL.
europepmc   +1 more source

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