Results 21 to 30 of about 16,888 (136)
Roles of Sema3C on Breast Cancer Angiogenesis and Metastasis [PDF]
, 2012 神经系统的发育依赖于一系列导向系统的控制。近年来的研究结果表明，神经导向系统不仅调控神经系统的发育，在血管新生和肿瘤发展等方面也发挥着重要的调控作用。神经生长导向因子Class3semaphorins（Sema3s）是脊椎动物中semaphorin家族中唯一一个的分泌型亚族。在Sema3s家族中的大部分成员在肿瘤发展过程中起抑制作用，而Sema3C却可能是一个促进肿瘤发展的因子。目前对于Sema3C在肿瘤中的作用主要集中在对肿瘤迁移、侵袭的影响等方面，对于肿瘤血管新生的影响还未见报道 ...
叶丽颖
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
The study of Angiopoietin -1 gene-modified endothelial progenitor cells transplantation in repairing rat balloon injury artery [PDF]
, 2011 目的：体外培养大鼠血管生成素－1(Angiopoeitin-1，Ang-1)基因修饰内皮祖细胞(endothelialprogenitorcell，EPC)，即(Ang-1-EPCs)。构建股动脉球囊损伤的大鼠模型。探讨Ang-1基因修饰的EPCs对大鼠急性球囊损伤动脉血管的修复作用。 方法：大鼠股动脉经球囊损伤后2天，扫描电镜观察其内皮损伤情况。动物实验分三组：对照组、单纯损伤组、细胞移植组；细胞移植组包括EPCs移植组（n=16），PNL-EPCs移植组（n=16）及Ang1-EPCs移植组（n ...
韩潇
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Integrative Conservation, Volume 4, Issue 4, Page 652-664, December 2025.We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene +5 more
wiley +1 more source
The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy [PDF]
, 2017 背景：肝细胞癌(Hepatocellularcarcinoma，HCC，简称肝癌)是我国常见恶性肿瘤之一，具有恶性程度高、生存时间较短、易转移复发、预后差等特点，死亡率在全世界所有肿瘤中高居第3位。我国肝癌高发，在肿瘤相关死亡中仅次于肺癌，居第2位。目前化疗(chemotherapy)是肿瘤治疗的常用手段，但同时易引起肝肾功能异常，导致骨髓抑制、消化道损伤，出现白细胞减少、恶心呕吐、食欲不振、腹痛腹泻、便秘等不良反应。西医尚缺乏具有良好疗效缓解化疗毒副反应的西药；中医临床诊疗实践发现 ...
彭樱
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Review of additively manufactured zinc alloys by laser powder bed fusion for biomedical applications
Rare Metals, Volume 44, Issue 11, Page 8262-8291, November 2025.Graphical abstract AbstractZinc (Zn) and its alloys have emerged as promising candidates for biomedical materials, owing to their controlled degradation kinetics, intrinsic biocompatibility, and the release Zn2+ ions which are known to promote bone regeneration and tissue healing.
Xuan Yang +5 more
wiley +1 more source
Angiopoient-1 regulate the inflammation of endothelial progenitor cells through NF-κB signaling pathway [PDF]
, 2011 内皮损伤和炎症是动脉粥样硬化的主要特点。修复内皮细胞功能已成为防治动脉粥样硬化的靶点。我们在前期研究中发现：诱导大鼠的内皮祖细胞（endothelialprogenitorcells，EPCs)炎症时，经下调EPC中ABIN-2蛋白的表达，Ang-1对炎症反应的抑制作用消失。ABIN-2蛋白是NF-kB内源性抑制物，能够抑制NF-kB的活性，而在调节炎症反应的信号通路中，NF-kB信号途径被认为是经典的一条途径。那么Ang-1调节炎症反应是否通过抑制NF-kB发挥作用？为此，我们使用NF ...
王锡煌
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Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 1, Page 85-93, January 2025.ABSTRACT Objective Accurate differentiation between placenta accreta spectrum (PAS) and uterine‐scar dehiscence with underlying non‐adherent placenta is often challenging, even for PAS experts, both prenatally and intraoperatively. We investigated the use of standardized two‐dimensional grayscale ultrasound and Doppler imaging markers in ...
T. Adu‐Bredu +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2019 1平阳霉素概述平阳霉素能够对血管瘤内皮细胞DNA合成与复制产生抑制作用,使血管内皮细胞的增殖受到抑制,破坏血管内皮,干预肿瘤细胞代谢功能,并且降低细胞的应激和毒性反应力,使血管瘤腔闭塞,结缔组织增生,从而达到瘤体消退的目的[2]。治疗血管瘤的有效成分:平阳霉素为博来霉素A5,博来霉素主要是两种化合物(A2和B2)的混合物,平阳霉素的化学结构类似于博来霉素,在抗肿瘤方面A5与A2疗效基本相同,在毒性方面A5比A2低,A5对造血系统、免疫系统功能损伤甚微 ...
苏雨 +5 more
doaj
Ang-1 gene affect the inflammation of endothelial progenitor cells through NF-Kappa B signaling pathway [PDF]
, 2010 基因修饰后的干细胞治疗动脉粥样硬化是近年来出现的动脉粥样硬化治疗的新策略。通过基因修饰可以增强干细胞修复血管的能力。本课题组前期实验中，我们发现Ang-1能够抑制TNF-a诱导的内皮祖细胞炎症反应，增强EPC细胞修复血管损伤的能力，但其具体的生物学机制并不明确。有研究发现在仓鼠的卵巢细胞中Ang-1通过Tie-2受体磷酸化招募ABIN-2蛋白抑制NF-kappaB信号传导通路，达到抑制炎症反应的作用。在内皮祖细胞中，Ang-1与NF-kappaB信号传导通路之间的是否同样存在这种联系目前并未见报道。为此，
刘一叶
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