Results 1 to 10 of about 1,715 (91)
[Rapid identification and analysis of hemoglobin isoelectric focusing electrophoresis images based on deep learning]. [PDF]
Se Pu基于轮廓分析的传统条带检测算法步骤繁琐，并且需要校正算法来应对背景不均匀、泳道扭曲和条带变形等问题。为了避免校正算法在检测过程中给条带分析结果所带来的误差，本文提出了一种基于深度学习目标检测算法的凝胶电泳图谱条带快速识别方法，并将该方法应用于血红蛋白（Hb）等电聚焦（IEF）电泳图谱的分析中。将通过微阵列IEF（mIEF）电泳实验收集的1 665张Hb IEF电泳图谱作为训练数据集，结合YOLOv8模型进行训练。依据模型推理得到的条带边界框位置和分类结果，对条带区域的像素灰度强度进行加和 ...
Ji WC +6 more
europepmc +2 more sources
Thalassemia Reports, 2017 Patients with thalassemia major who received allogeneic hematopoietic cell transplantation are at increased risk of gonadal insufficiency and reduced fertility due to the toxicity of both the transfusional iron overload and the gonadotoxic effects of ...
Nicoletta Iacovidou +7 more
doaj +3 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 了解深圳地区育龄人群中α?β地中海贫血基因型的分布情况?【方法】 通过检测育龄男女外周血的平均红细胞容积(MCV)?平均红细胞血红蛋白含量(MCH)和血红蛋白电泳进行地中海贫血的筛查?对于6 276例筛查阳性者用PCR及反向斑点膜条杂交技术(Reverse Dot Blot Hybridization,RDB法)进行α?β地中海贫血基因诊断,未检查到常见突变者进一步行基因突变热点测序?比对检测?【结果】 5 503例进行了α地贫基因诊断,共检出11种α地贫基因型共2 129例 ...
doaj +1 more source
基于微阵列聚焦电泳的糖尿病血样临床阳离子交换高效液相色谱图中血红蛋白A3峰位置推测
Se pu = Chinese journal of chromatography, 2021 血红蛋白A1c(HbA1c)是糖尿病诊断的关键生物标志物,目前其常用的分析方法为阳离子交换高效液相色谱法(CX-HPLC, 5/50 mm分离柱),此方法虽然具有稳定、快捷与自动化等众多优点,但临床CX-HPLC(VARIANT Ⅱ system)谱图中仍存在未知峰,尤其干扰HbA1c准确测定的谷胱甘肽化血红蛋白A3(HbA3)在色谱图中的相对位置仍不清楚。针对这一问题,该文以人新鲜血液为样本,首先利用低分辨CX-HPLC对血样进行分析,提示未知峰P3存在。然后通过微阵列等电聚焦(IEF ...
Zehua Guo +5 more
semanticscholar +1 more source
Two familial cases of Hb Tyne confirm instability as cause of low expression
Thalassemia Reports, 2017 We report a second occurrence of hemoglobin (Hb) Tyne, [β5 (A2) Pro>Ser] HBB:c.16C>T(p.Pro6Ser), which like the first case was associated with normal hematology.
Beverley M. Pullon, Stephen O. Brennan
doaj +1 more source
Research progress and considerations for thalassemia gene therapy [PDF]
Traditional treatment modalities for thalassemia include regular blood transfusions and allogenic hematopoietic stem cell transplantation (allo-HSCT). In recent years, autologous transplantation of gene-modified hematopoietic stem cells has emerged as a ...
GAO Xinjie, LIU Yan, WANG Dawei
core +1 more source
Thalassemia Reports, 2017 Thalassemias and hemoglobinopathies are the most common hemolytic congenital disorders in Bangladesh as in many parts of the world. This study was done to find the common types of thalassemias and abnormal hemoglobin variants seen in Bangladeshi ...
Waqar A. Khan +3 more
doaj +1 more source
Zhongguo shiyan zhenduanxue, 2021 华氏巨球蛋白血症(Waldenstr9m’s macroglobulinemia,WM)是以淋巴浆细胞浸润骨髓同时伴血清单克隆性免疫球蛋白IgM增高为特点的惰性成熟B细胞淋巴瘤[1]。该病是一种少见的惰性成熟B细胞淋巴瘤,约占血液系统恶性肿瘤的1%-2%[2]。WM临床表现无特异性,容易漏诊、误诊。WM相关的肾损害在临床中比较少见。为此报道1例以轻链沉积病为首发表现的WM,以提高临床工作者对本病的认识。1临床资料患者,男,61岁。因"眼睑及四肢水肿伴乏力、气短8天 ...
杨婷, 胡晓, 沈卫章
doaj
Analysis on gene detection results of 3715 cases with thalassemia in Xiamen [PDF]
, 2015 目的:调查厦门地区地中海贫血基因的携带率、基因突变类型及其频率分布。方法:对2013年1月~2014年8月在该院住院或门诊治疗的患者及健康体检人员共3 715例进行地中海贫血基因检测,对检测结果进行统计分析。结果:检测出静止型α-地中海贫血200例(5.4%),中间型α-地中海贫血44例(1.2%),标准型α-地中海贫血1 213例(32.6%),β-地中海贫血787例(21.2%),α-合并β-地中海贫血69例(1.8%)。结论:不同就诊对象地中海贫血检出率具有明显差异 ...
刘洪雪 +5 more
core
Thalassemia Reports, 2017 Glycosylated hemoglobin (GHb) is routinely used to monitor glycemic control over past 2-3 months in diabetics. As per the recommendations of the American Association of Clinical Endocrinologist, 2007 values should be maintained below 7% to prevent the ...
Sarita Pradhan +2 more
doaj +1 more source