Results 21 to 30 of about 9,116 (165)
High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural medicinal plants [PDF]
, 2016 酶是治疗多种疾病的重要靶标，乙酰胆碱酯酶（AChE）的抑制剂是现阶段治疗阿尔兹海默症（AD）最有效的一类药物。从天然产物中寻找适宜患者长期服用、毒副作用小、作用面广等优点的乙酰胆碱酯酶抑制剂（AChEIs）受到了科研工作者的广泛关注。本论文以AChE作为药物靶标，构建基于高效液相色谱-质谱联用技术（HPLC-MS）的在线生物活性检测方法，发展集分离纯化、结构确证和活性筛选于一体的活性导向天然产物研究方法，用来寻找和发现天然药用植物中潜在的AChEIs候选化合物 ...
刘静兰
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Conservation Biology, Volume 40, Issue 1, February 2026.Abstract Urgency to save species from extinction has prompted increased investment in law enforcement in protected areas. To date, such law enforcement has largely focused on increasing costs and reducing opportunities for offending. However, these resource‐intensive approaches are not always effective and can contribute to conflict between people and ...
Freya A. V. St. John +3 more
wiley +1 more source
oleoylethanolamide improves spatial cognitive deficits through enhancing hippocampal neurogenesis after cerebral ischemia [PDF]
, 2015 我们先前的研究表明油酰乙醇胺（OEA）对急性脑缺血损伤具有神经保护作用。本研究的目的是探讨OEA对脑缺血引起的空间认知障碍，海马长时程增强作用（LTP）的抑制作用和海马神经发生的影响。结果表明：OEA30mg/kg显著改善大鼠脑缺血后空间认知功能障碍，促进海马长时程增强。另外，我们证实OEA通过促进海马神经发生改善脑缺血后的认知障碍。进一步的研究表明，OEA明显增加海马组织脑源性神经营养因子（BDNF）和过氧化物酶体增殖活化受体（PPARα）的表达 ...
杨立朝
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International Journal of Applied Linguistics, Volume 36, Issue 1, Page 522-539, February 2026.ABSTRACT This paper examines the features of metadiscourse across different teacher moves in university linguistics classroom discourse and the teaching strategies reflected in its use. The results reveal that teachers employ diverse metadiscourse during classroom interactions to support student reasoning.
Jingjie Li, Wenjie Hu
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 认知功能是大脑高级皮质功能的重要内容,痴呆早期的重要临床特征表现为认知功能的损害。高血压是心脑血管疾病的重要危险因子,并与认知功能减退及痴呆的发生有着密切关系。而血压节律变化对血管性认知障碍(VCI)的影响,尤其对VCI各认知域影响的研究较少。本研究通过对伴有高血压的VCI患者行24小时动态血压节律监测并结合认知功能评估,探讨血压节律变化对血管性认知功能障碍的影响 ...
路超 +5 more
doaj
Risk Factors of Caregiver Burden in Patients With Cognitive Dysfunction: A Scoping Review
Brain and Behavior, Volume 16, Issue 1, January 2026.This scoping review identifies neuropsychiatric symptoms and behaviors as the core risk factor for caregiver burden in cognitive dysfunction, with functional dependence and female caregivers as key drivers. Findings underscore the need for targeted, multi‐domain interventions to alleviate burden across diverse caregiving contexts.
Liu Jinheng +5 more
wiley +1 more source
高脂饮食造成认知功能损伤的机制探索Mechanism exploration of cognitive impairment caused by high fat diet
Zhongguo youzhi长期的高脂饮食（HFD）会造成大脑能量代谢紊乱，引发认知障碍，影响大脑功能。旨在为膳食营养或临床手段改善HFD介导的认知功能障碍提供理论基础,系统梳理了HFD造成认知功能损伤的机制。HFD通过神经炎症、氧化应激、线粒体功能障碍、胰岛素抵抗、血脑屏障受损、表观遗传紊乱和破坏突触可塑性等途径的单一或复合作用，造成大脑认知功能受损或下降。未来研究应进一步探索大脑代谢性损伤的确切机制，并通过研究提供预防或治疗HFD造成的认知功能障碍的有效手段。 Long-term high fat diet (HFD ...
刘玲馨，王阳，朱毅 LIU Lingxin，WANG Yang，ZHU Yi
doaj +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT High‐entropy alloys (HEAs) have emerged as a transformative class of materials distinguished by their complex chemical compositions, unique microstructures, and remarkable mechanical and functional properties. Traditionally, the discovery and optimization of HEAs have relied on conventional methods, including trial‐and‐error experimentation ...
Chrispin Ouko Zamzu +2 more
wiley +1 more source
, 2019 目的了解高龄老人认知能力状况,分析其影响因素。方法利用1998～2011年高龄老人健康长寿观测服务调查问卷(CLHLS)的六期数据,选取其中80岁及以上老年人为研究对象,采用多水平模型分析高龄老人的认知功能动态变化及其影响因素。结果共纳入128例高龄老人。受调查者的认知功能随着年龄的增长并无显著下降趋势(P=0.834)。女性的认知功能显著低于男性(P=0.011),且其认知功能下降速度快于男性(P=0.015)。日常生活自理能力和休闲活动的参加程度显著影响高龄老人的认知功能 ...
徐昊楠, 李珍, 王德文
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Integrative Conservation, Volume 4, Issue 4, Page 546-554, December 2025.Desertification is increasing in the Brazilian Semiarid, leading to loss of species and ecosystem services, while precise data on biodiversity distribution and trends are lacking. Public engagement in scientific projects can improve ecosystem protection.
Lucas Rodriguez Forti +3 more
wiley +1 more source