Results 51 to 60 of about 9,116 (165)
The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]
, 2016 细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
core
Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 2, Page 133-147, March 2025.Abstract Differences in mind‐mindedness and parental reflective functioning (PRF) were investigated in mothers and their 6‐month‐old infants from South Korea (N = 66, 32 girls) and the United Kingdom (N = 63, 26 girls). Mind‐mindedness was assessed in terms of appropriate and non‐attuned mind‐related comments during infant–mother interaction; PRF was ...
Yujin Lee +2 more
wiley +1 more source
脑血管储备功能在伴大脑中动脉狭窄的急性缺血性卒中后认知障碍中作用的临床研究
Zhongguo shiyan zhenduanxue, 2017 目的研究脑血管储备功能在伴大脑中动脉狭窄的急性缺血性卒中后认知障碍的动态变化。方法对正常对照组及伴大脑中动脉狭窄的急性缺血性卒中后认知障碍患者进行MMSE量表评分,应用经颅多普勒进行脑血管储备功能检测,3个月后复查上述指标。结果急性卒中后认知障碍患者（MCASCI组）屏气指数（BHI）及Vm上升率（%）明显降低 ...
张馨, 李丽, 李淞
doaj
Research on the elderly disability in Xiamen [PDF]
, 2015 目的 中国老龄化形势严峻，与之相伴而生的老年人失能问题也急剧凸显。本文拟通过对厦门市老年人失能问题的调查研究，了解厦门市失能老年人的数量、程度、分布特征，失能原因及照护现状，并分析失能相关的影响因素及失能对老年人健康状况带来的影响，为开展老年人失能预防控制工作和完善失能老年人社会保障体系提供循证依据。 方法 1.采用多阶段抽样的方法，抽取厦门市60岁及以上户籍老年人作为调查对象。开展面对面问卷调查，调查内容包括基本信息、失能原因、失能老年人照护现状、日常生活自理能力和健康状况。 2 ...
陈炜
core
The effect of personalized intervention on the cognitive function of elderly inpatients [PDF]
目的 对住院老年患者进行早期认知功能护理干预，评价其效果。方法 2013年1月—2015年1月入院老年科病房的120名患者，运用MMSE量表对其认知功能进行评价，观察干预效果。结果 MMSE总分及MMSE量表中时间定向、短期记忆及插画条目干预后有改善（P＜0.05），地点定向、语言记忆、注意力、物品命名、语言复述、阅读能力、语言能力及语言表达条目改善不明显（P＞0.05）。 结论 个性化的认知干预能够延缓和改善患者认知功能障碍，提高老年患者的生活质量。Objectives: To assess ...
Fang, Ya-zhen +5 more
core +2 more sources
Integrative Conservation, Volume 4, Issue 1, Page 20-32, March 2025.This study examined the impact of a 9‐day naturalist training camp at the Xishuangbanna Tropical Botanical Garden on participants' conservation attitudes and mental well‐being. Findings showed significant improvements in biodiversity knowledge, social connectedness, and naturalist identity, which contributed to increased environmental stewardship and ...
Yichuan Meng, Jiangbo Zhao, Jin Chen
wiley +1 more source
Research on hypothetical interventions of cognitive impairment among Chinese older adults: Analysis based on the G-formula model [PDF]
, 2017 目的 中国老龄化问题日益严峻，随之相伴的老年性疾病也得到越来越多的关注，其中认知功能障碍已成为老龄化社会最常见的疾病之一，严重影响老年人的生活质量。由于以往现场干预研究存在随访时间短、干预因素和研究人群局限等问题，本文将利用G-formula模拟干预模型，解决以上不足之处，并从统计因果推断的角度分析社会心理和饮食因素对我国65岁以上老年人认知功能障碍的影响，为降低认知功能障碍的发生、提高老年人生活质量及实现健康老龄化提供科学理论依据。 方法 ...
符健
core
Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 1, March 2025.Abstract How are trust and reslience related? There is a lack of conceptual discussions. This paper analyzes trust and resilience with respect to the system of critical infrastructures and engineers working on critical infrastructure resilience. The results are three findings based on the assumption that resilience and trust are mechanisms to cope with
Benjamin Scharte
wiley +1 more source
Changes of serum uric acid, bilirubin and homocysteine levels in patients with early Parkinson’s disease [PDF]
目的 观察早期帕金森病并伴有轻度认知功能障碍（PD-MCI）患者血清间接胆红素（IBIL）、尿酸（UA）、同型半胱氨酸（Hcy）及尿酸/同型半胱氨酸比值（UA/Hcy）的变化，探讨其与PD-MCI的关系。 方法 收集158例早期未经药物治疗的帕金森病（PD）患者的人口学及临床资料，应用Hoehn & Yahr分级评估PD严重程度，MDS-UPDRS III评估运动障碍，蒙特利尔认知评估量表（MoCA）评估全面认知功能状态。102例年龄匹配的健康体检者作为对照组。检测各组血清IBIL ...
Li, Zhen-guang +2 more
core +2 more sources
Examining the structure of plant–lemur interactions in the face of imperfect knowledge
Conservation Biology, Volume 39, Issue 1, February 2025.Abstract Biotic interactions, such as plant–animal seed dispersal mutualisms, are essential for ecosystem function. Such interactions are threatened by the possible extinction of the animal partners. Using a data set that includes plant–lemur interactions across Madagascar, we studied the current state of knowledge of these interactions and their ...
Jadelys Tonos +6 more
wiley +1 more source