Results 21 to 30 of about 26,619 (170)
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Developing Cu‐based composites that simultaneously achieve ultra‐high strength, ductility, and electrical conductivity remains critical for advanced electrical contact applications. In this work, multiphase AlCrCuFeNi2.5 high‐entropy alloy (HEA) reinforcements are incorporated into CuCrZr matrix via spark plasma sintering (SPS) and annealing ...
Tao Hong +8 more
wiley +1 more source
诱导耐药型宋内志贺菌中主动外排阻遏基因acrR、marR的变化
Zhongguo shiyan zhenduanxue, 2015 目的分析宋内志贺菌在被环丙沙星诱导耐药后其主动外排阻遏基因acrR、marR突变与表达量的变化。方法通过1/2MIC逐级诱导宋内志贺菌对环丙沙星耐药,通过提取诱导株诱导前后DNA和总RNA,采用基因测序检测突变和实时荧光定量PCR方法检测acrR、marR基因表达量的变化。结果 2株诱导耐药株中acrR、marR中均不存在基因突变,相对于诱导前acrR、marR Ct值增加,基因表达量降低。结论 acrR、marR基因表达量降低间接导致主动外排基因acrAB-tolC转录水平提高 ...
高佩增, 姚明晓
doaj
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang +14 more
wiley +1 more source
黄酮与黄酮醇类化合物对HepG2细胞中CYP1A1mRNA表达的影响
Zhongguo shiyan zhenduanxue, 2008 目的观察15种黄酮与黄酮醇类化合物对细胞色素P450酶（cytochrome P450,CYP）1A1基因表达的影响。方法采用实时定量PCR技术检测HepG2细胞中各CYP1A1mRNA的表达。结果黄酮、6-羟基黄酮、槲皮素、黄芩素、野黄芩苷、野黄芩素和白杨黄素是CYP1A1的强诱导剂,50uM浓度时诱导超过10倍;黄芩苷是中等程度诱导剂,诱导倍数为7.68;桑黄素、木犀草素、汉黄芩素和山萘酚是CYP1A1弱诱导剂,诱导倍数在2-3倍左右。而7-羟基黄酮、漆黄素、芹菜黄素是CYP1A1的弱抑制剂 ...
郭颖杰, 康治臣, 张家剑, 周慧
doaj
The mechanism of BaP and DDT co-exposure induced DNA damage via MAPK signal pathway [PDF]
, 2016 【目的】 苯并(a)芘(benzo[a]pyrene，BaP)是多环芳烃类化合物的典型代表之一，于各种环境介质中广泛存在，具有很强的致癌性，被国际癌症研究机构列为1类致癌物。滴滴涕(2，2-bis(4-chlorophenyl)-1，1，1-trichloroethane，DDT)曾是生产及使用范围最广的一类有机氯农药，在环境中非常难于降解，具有高亲脂性，可以对哺乳动物的肝脏、肾脏、神经等系统造成损害。BaP和DDT常共存于环境并可通过食物链的生物放大作用富集于人体，危害人类健康。因此 ...
刘敏
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT The development of efficient and stable bifunctional catalysts remains a key challenge for green hydrogen production via electrochemical water splitting. In this study, a bimetallic Mo/Fe‐doped CoP2 nanoleaf array anchored on carbon cloth (Mo, Fe‐CoP2@CC) was synthesized from zeolitic imidazolate framework‐L (ZIF‐L) via an ion‐exchange and low‐
Xiangqun Zeng +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 目的探讨人羊膜上皮细胞体外向神经样细胞诱导分化的条件。方法碱性成纤维细胞生长因子预诱导剂（bFGF）,化学诱导剂全反式维甲酸（ATRA）、丁酸羟基茴香醚（BHA）作为诱导剂,并以不含诱导剂的无血清的MEM培养基作为对照,密切观察分化过程中细胞形态的变化,诱导至6 h、12 h、24 h时,利用免疫细胞化学方法检测神经元特异性标志物的表达情况。结果诱导分化12 h后的ATRA组大部分细胞呈现双极、多极和锥形的典型神经元细胞的形态,免疫细胞化学显示这些细胞表现为NSE染色阳性,而丁酸羟基茴香醚（BHA ...
刘红敏, 陈旭东, 华新宇
doaj
HUVECs Promote the Proliferation of iPS-MSCs by FAM3B [PDF]
, 2016 间充质干细胞（mesenchymalstemcells，MSCs）存在于一个血管周微环境中，在这个微环境内，内皮细胞（endothelialcells，ECs）与MSCs互相作用，调控MSCs的表型和增殖，从而在MSCs的血管生成作用和治疗应用方面起重要作用。然而，MSCs受到来源、年龄、健康等多方面的影响，不能满足大规模的使用需求。诱导多能干细胞来源的间充质干细胞（inducedpluripotentstemcell-derivedMSCs，iPS-MSCs）可能会是一个有前景的替代性干细胞来源。但是，
冷云
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Expanding near‐infrared (NIR) spectral response and utilizing ultraviolet (UV) photons are effective strategies for enhancing the power conversion efficiency (PCE) of lead halide perovskite solar cells (PSCs). However, the range of NIR spectral response extension and the utilization of UV light for devices are not enough, and the loss of ...
Li He +9 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source