Results 21 to 30 of about 7,099 (167)
Altered plasma cytokines in dogs with atopic dermatitis
Veterinary Dermatology, Volume 33, Issue 2, Page 131-e38, April 2022., 2022 Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier +3 more
wiley +1 more source
Veterinary Dermatology, Volume 32, Issue 4, Page 331-e92, August 2021., 2021 Background MicroRNAs (miRNA) are short, single‐stranded RNA molecules that regulate gene expression in a post‐transcriptional manner. Their expression is proposed to be tissue‐specific and alterations in miRNA expression have been detected in many diseases. Objective To compare miRNA expression in the skin of healthy Labrador and golden retrievers, and
Marie Isabel Morlang +3 more
wiley +1 more source
野生动物学报, 2022 季节性繁殖是哺乳动物在长期的进化过程中,为了应对外界环境的变化,选择合适的季节进行繁殖的行为。雄性哺乳动物在非繁殖季节表现为睾丸退化,精子发生的减数分裂过程受阻,进入繁殖季节性腺恢复,重新启动精原细胞的分裂和分化,这种季节性精原细胞分裂和分化与精子发生受到环境因子和多种体内激素的调节。就光周期信号分子——褪黑激素通过TSH-DIO2/DIO3-T3逆行通路和HPG轴—睾酮—视黄酸信号系统对雄性哺乳动物繁殖季节性调控的研究综述可知:褪黑激素通过调控HPG轴的功能促进精子的发生 ...
杨 笛, 陈婉依, 宫泽儒, 杨 明
doaj
Journal of Diabetes, Volume 12, Issue 9, Page 649-658, September 2020., 2020 Highlights Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2; recent modeling of the structure of SARS‐CoV‐2 spike glycoprotein, which mediates viral‐host‐cell entry, predicts interactions with dipeptidyl peptidase 4 (DPP4) in addition to angiotensin‐converting enzyme 2.
Margaret F. Bassendine +3 more
wiley +1 more source
Arsenic Trioxide Induces T cell Apoptosis and Prolongs Islet Allograft Survival in Mice [PDF]
, 2015 目的：作为一种最有潜力的I型糖尿病的治疗方法，胰岛移植目前已经应用于临床。然而，免疫因素特别是T细胞介导的移植物活性损伤与功能丧失是胰岛移植应用的一大障碍。一直以来，科学家们都在寻找适用于胰岛移植的新型免疫抑制剂。三氧化二砷是临床上治疗早幼粒细胞白血病的特效药，最近被证明能够抑制同种异体心脏移植排斥反应。在此基础上，本文研究了三氧化二砷对同种异体胰岛移植免疫排斥的抑制作用，以及三氧化二砷与雷帕霉素联合诱导免疫耐受的可能作用机制。 方法：我们首先检测了三氧化二砷对胰岛细胞的毒性作用 ...
高畅
core +1 more source
Zhongguo shiyan zhenduanxue, 2022 多发性骨髓瘤（MM）是一种起源于骨髓的浆细胞恶性克隆增殖性疾病，好发于中老年人[1]，发病率逐年增加，是血液系统较为常见恶性肿瘤。大多数患者随着近些年来免疫调节剂和蛋白酶体抑制剂的临床应用后总体生存率有显著提高，患者生存质量得以改善，然而难治性和复发性骨髓瘤患者的治疗效果不尽如人意。人CD38抗原为单链Ⅱ型跨膜糖蛋白，长度为45kDa，调节细胞活化、分化和增殖[2]，通常在造血干细胞、T细胞、NK细胞和树突细胞中表达，外周血中性粒细胞和B淋巴细胞不表达，骨髓瘤细胞高量表达 ...
强新晨, 杨华莹, 邵俊良
doaj
铁死亡相关基因热休克蛋白A5与肝细胞癌因果关系的孟德尔随机化和中介分析
浙江大学学报. 医学版目的探讨铁死亡相关基因热休克蛋白A5（HSPA5）与肝癌发展的因果关系及其作用机制。方法采用两步两样本孟德尔随机化（MR）设计评估HSPA5、调节性T细胞及肝癌之间的因果关系。首先通过公开的全基因组关联研究（GWAS）数据库筛选与HSPA5、调节性T细胞、肝癌相关的单核苷酸多态性作为工具变量，采用MR分析HSPA5对肝癌的直接影响，接着通过两步MR分析调节性T细胞在这一过程中可能的中介作用。同时，以肝癌为暴露因素，HSPA5为结局变量进行了反向MR分析 ...
崔 兵 +5 more
doaj +1 more source
Maintenance of Long-term Tolerance by T Regulatory Cells in a Mouse Model of Heart Transplantation [PDF]
, 2015 目的：自20世纪以来，临床上心脏移植的一年生存率已经达到90%，但是移植后的慢性排斥以及长期存活仍面临巨大挑战，目前临床上所用的免疫抑制剂多数都必须终身用药，从而会产生多种副作用，危害受者的健康，影响患者的生活质量，所以如何诱导移植物的长期耐受是器官移植面临的重大难题。调节性T细胞是具有免疫调节功能的T细胞亚群,在移植后诱导和维持免疫耐受方面发挥重要作用。其中，CD4+CD25+Foxp3+T细胞（CD4+Foxp3+Treg）主要通过细胞接触发挥调节作用，而CD4+IL-10+IL-4-T细胞(Tr1)
靳宁
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
The Systemic Evaluation and Clinical Significance of Immunological Function for Advanced Lung Cancer Patients [PDF]
, 2010 Background and objective The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time.
Hui ZHANG +12 more
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