采用体外造血细胞培养技术,应用高温、利多卡因、足叶乙苷(足叶乙甙,VP-16)联合法,研究其在体外对白血病细胞的杀伤作用。结果表明:高温、利多卡因、VP-16三者联用比高温+利多卡因、高温+VP-16,能更有效地杀伤白血病细胞,而正常粒单系克隆形成单位(GM-CFU)仍约有50%存活。41℃60min+0.75mmol/L利多卡因+8.5μmol/LVP-16联合处理后,HL-60、U937、K562细胞分别只存活0.01%、9.40%、33.66%。另外,从这个联合方案说明对于不同类型的白血病效果不一,
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内质网是维持细胞蛋白稳态的重要细胞器,通过未折叠蛋白反应(unfolded protein response,UPR)来调节细胞 蛋白合成、折叠和降解。UPR维持内质网功能和稳态,多种病理生理因素如缺血缺氧、毒物、高血糖、脂质代谢紊乱都能诱 发肾脏细胞内质网应激反应。发生内质网应激时,UPR相关3种不同细胞信号途径激活,一方面增加分子伴侣合成,协助蛋 白分泌,另一方面减少靶蛋白合成,减轻内质网负荷;同时诱导细胞凋亡或自噬。多种肾脏疾病与UPR或内质网应激反应 不足或过度有关 ...
王蔚东
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[<i>Guijianyu</i> alleviates advanced glycation endproducts-induced mouse renal podocyte injury by inhibiting the AGEs-RAGE signaling pathway]. [PDF]
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Period circadian clock 3 inhibits palmitic acid-induced oxidative stress and inflammatory factor secretion in podocytes. [PDF]
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Yiqi Yangyin Huazhuo Tongluo Formula alleviates diabetic podocyte injury by regulating miR-21a-5p/FoxO1/PINK1-mediated mitochondrial autophagy. [PDF]
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EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway. [PDF]
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[Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]. [PDF]
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