Results 31 to 40 of about 4,880 (164)

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu   +5 more
wiley   +1 more source

Study on the Function of the Neuron-Specific Protein TMEM59L in the Central Nervous System and in Oxidative Stress-Induced Cell Death [PDF]

open access: yes, 2016
细胞凋亡是受基因严格调控的、自然发生的程序性细胞死亡过程,而细胞自噬是细胞组分自我降解的过程,二者在发育、组织稳态以及病原体防御中扮演着重要角色。细胞凋亡和细胞自噬发生异常会引发多种疾病包括癌症和神经系统疾病。神经元对于氧化应激十分敏感,并易于受到活性氧的攻击;当神经元长期暴露于包括过氧化氢在内的活性氧的攻击时会引发细胞死亡,导致各种神经系统疾病。因此,鉴定参与神经元死亡的新基因蛋白并揭示其作用机制,将有助于阐明神经系统疾病的致病机理。 TMEM59L为新发现的脑特异性高表达蛋白 ...
郑秋阳
core  

Synergy of Built‐In Electric Field and Surface Reconstruction of Co–NiS/Ni3S2 Nanowires for Enhanced Bifunctional Activity and Anti‐Chlorine Corrosion in Seawater Electrolysis

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT The development of efficient and stable bifunctional electrocatalysts is a key challenge for the industrialization of hydrogen production by water electrolysis. In this work, Co‐doped NiS/Ni3S2 heterostructured nanowire arrays (Co–NiS/Ni3S2 NA) were successfully constructed by precisely modulating the phase‐selective behavior of nickel ...
Xing‐Hang Liu   +2 more
wiley   +1 more source

鼻咽癌患者血中谷胱甘肽过氧化物酶活性的初步研究

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1988
硒(Se)是人体必需微量元素,在营养生理学允许量范围内,硒能阻止或延缓病毒、化学致癌物对肿瘤的诱发而产生的致癌作用。谷胱甘肽过氧化物酶(GSH—PX)是硒依赖性的,硒作为谷胱甘肽过氧化物酶的一种重要成分来还原脂质氢过氧化物,使还原型谷胱甘肽(GSH)转变成氧化型谷胱甘肽(GSSG),这样就可破坏脂质氢过氧化物对机体带来的损害,保护细胞膜和组织对抗脂质过氧化反应所引起的破坏作用,维持细胞正常的生物功能。
郑美莲
doaj  

The association between the antioxidant property and ROS system in murine corneal epithelial progenitor cells [PDF]

open access: yes, 2016
目的:活性氧(ROS)是体内产生的一种高活性分子,低浓度可以调节细胞代谢,基因转录和磷酸酶的活性,高浓度则会导致氧化损伤。目前,有关干细胞自身特性的研究越来越受到学者们的重视,但既往文献中关于干细胞对氧化应激反应以及应激条件下细胞内相关酶活性的变化规律却很少报道。本课题聚焦于,在过氧化氢(H2O2)诱导的氧化应激条件下,活性氧生成关键因子NOX4和抗氧化酶核转录因子NRF2在小鼠角膜上皮祖细胞(TKE2)和成熟的小鼠角膜上皮细胞(MCE)中的不同作用及相关机制。 方法:利用小鼠角膜上皮祖细胞(TKE2 ...
周晶
core  

Phosphorus‐Doping Drives the Formation of a Pt‐Skin@PtFe Alloy Catalyst With Modulated d‐Band Center for Oxygen Reduction

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Platinum (Pt)‐based catalysts are crucial for the commercialization of hydrogen/metal air batteries, but they suffer from Pt scarcity, high cost, and nanoparticle dissolution/agglomeration, mainly leading to performance degradation. We address this by synthesizing a PtFe alloy catalyst (PtFe–PA–NC) via a phytic acid (PA) assisted pyrolysis ...
Chenyang Shu   +9 more
wiley   +1 more source

Danggui sini Decoction attenuated diabetic neuropathy in diabetic rats [PDF]

open access: yes, 2016
摘要 目的:糖尿病神经病变(Diabeticneuropathy,DN)是糖尿病常见的并发症之一。我们以往的研究发现当归四逆汤加减方(DangguisiniDecoction,DSD)能够缓解糖尿病神经病变引起的疼痛。本实验拟观察当归四逆汤加减方(DSD)对糖尿病大鼠坐骨神经和脊髓中一氧化氮(nitricoxide,NO)、一氧化氮合酶(Inducednitricoxidesynthase,NOS)、抗氧化酶、凋亡相关蛋白和硝基酪氨酸(nitrotyrosine,NT)蛋白和对后肢爪垫表皮内神经纤维影响。
陈宁宁
core  

Tailoring Spin States of CuNNi3 via d‐d Orbital Coupling for High Performance Water Splitting

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Against the backdrop of escalating global energy crises and environmental challenges, the development of clean and sustainable hydrogen energy has become increasingly imperative. Hydrogen production via water electrolysis is widely regarded as a promising approach due to its green and efficient characteristics.
Weigao Zhong   +6 more
wiley   +1 more source

Hydrodeoxygenation of vanillin catalyzed by molybdenum carbide supported on activated carbon(以活性炭为载体的碳化钼催化剂在香兰素加氢脱氧反应中的作用)

open access: yesZhejiang Daxue xuebao. Lixue ban, 2015
XRD,TEM,N2-吸附等表征手段表明,在700 ℃下以碳热氢还原方法制备的粒径在1~4 nm的β-Mo2C,能够均匀分散在活性炭载体上.在温和条件(100 ℃,氢压1.0 MPa, 3 h)下,以水作为反应溶剂,质量分数为20.0%的Mo2C/AC催化剂催化香兰素的加氢脱氧反应转化率高达93.2%,2-甲氧基-4-甲基苯酚的选择性达到53.8%.随着负载量的增加,Mo2C/AC催化剂的比表面积呈下降趋势,其活性先增强后减弱,而当负载量增加到一定程度后,Mo2C粒子在载体上发生团聚 ...
HELili(何莉莉)   +3 more
doaj   +1 more source

New varieties of tomatoes with high resistance to disease and high yield - breeding of a Su Kang No. 7-9 (pink colour fruit) [PDF]

open access: yes, 1995
提要苏杭七号八号、九号番茄品种是江苏省农科院蔬茉所培育的粉果类型优良一代杂 种, 经所内多年品比试验、江苏省三年区域试验、生产示范及两年全国区试、生产试验, 均表现突出。该品种高杭烟草花叶病毒(TMV)、丰产、品质好、早、中、晚熟配套, 适 应性广, 适宜露地丰产栽培及保护地种植, 已在省内及全国广泛种植, 与当地主栽品种相比, 增产15~50%
Long, M, Lu, C, Xu, H, Yang, R, Yu, W
core  

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