Zhongshan Daxue xuebao. Yixue kexue ban急性肺损伤（ALI）是一种严重威胁全球人类生命健康的疾病，其主要病理特征为肺泡上皮细胞和肺毛细血管内皮细胞的损伤，导致弥漫性肺间质水肿和肺泡水肿，通常伴有急性低氧性呼吸功能不全。内质网应激（ERS）在ALI的发生和发展过程中扮演着关键角色。它通过多种途径加剧急性肺损伤：在细胞凋亡方面，关键蛋白如GRP78、CHOP和caspase-12参与调控，促进肺血管内皮细胞和肺泡上皮细胞的凋亡，从而加重肺组织损伤；在ROS代谢方面，诱导活性氧（ROS）的大量释放，NADPH氧化酶等参与ROS的产生过程 ...
韩英, 胡丹丹
doaj
[Research progress on cellular metabolic reprogramming in skin fibrosis]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanQian S, Dai S, Guo C, Xu J.
europepmc +1 more source
[Liver-bone axis: novel mechanisms and strategies for MAFLD regulation]. [PDF]
Zhonghua Gan Zang Bing Za ZhiWang YW, Yan XZ, You H, Yang AT.
europepmc +1 more source
[Research progress of inherited liver disease in 2025]. [PDF]
Zhonghua Gan Zang Bing Za ZhiTang S, Hou W, Duan ZP, Zheng SJ.
europepmc +1 more source
基于TCGA数据库分析铁死亡代谢和lncRNA在结直肠癌中的表达及临床意义
Zhongguo shiyan zhenduanxue结直肠癌是全世界范围内最为常见的消化道恶性肿瘤。近年来，结直肠癌发病率和死亡率均表现为逐年升高的趋势，严重威胁人类的身心健康，因为结直肠癌患者的早期临床症状较隐匿，多无明显症状，晚期则出现严重的症状，如贫血和体重减轻，多数患者自己察觉并至医院专业诊断时已至中晚期，到目前为止根治性的手术仍然是治疗结直肠癌的首选方案，但术后的高复发率、高转移率和低生存率等问题一直没有很好的解决，结直肠癌患者的预后仍然很差，因此寻找新的诊断和治疗方法是目前的首要任务[1-3]。
潘楠, 唐桂艳, 吕楠, 马太原
doaj
[Analysis of urine biomarkers in urothelial carcinoma based on untargeted metabolomics]. [PDF]
Se PuLiu S, Wang M, Wang W.
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[Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLi Z, Xu C, Xu R, Zhou C, Fan Y.
europepmc +1 more source
[Molecular Mechanism of Neutrophils Driving the Progression of Lung Adenocarcinoma]. [PDF]
Zhongguo Fei Ai Za ZhiLi X, Li L.
europepmc +1 more source
[Construction of a prognosis forecasting model for breast cancer based on lipid metabolism-related genes and functional verification of <i>ALDH2</i>]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanLu Z, Lu Y, Zhou J, Zhu Y.
europepmc +1 more source
[Application of chromatography-mass spectrometry in the clinical analysis of multiple sclerosis]. [PDF]
Se PuYao ZY +5 more
europepmc +1 more source