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Inhibitory Effect and Mechanism of Procyanidin B2 on High Glucose-Induced Ferroptosis in SH-SY5Y Cells [PDF]
Objective: To investigate the neuroprotective effect and mechanism of procyanidin B2 on high glucose-induced ferroptosis in differentiated SH-SY5Y cells.
WANG Jiaqi, CHEN Xiuting, XIA Xing, ZHOU Jinling
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Zhongguo shiyan zhenduanxue, 2014 NAFLD是遗传环境代谢应激相关性疾病[1-4]。近年来,人们发现在NAFLD的发病机制中,铁作为一种独立危险因素起着重要的作用。铁超负荷除了通过诱发氧应激造成过氧化损伤,还与胰岛素抵抗有着密切的关系。脂联素[5,6]作为一种改善胰岛素抵抗的保护性因子在NAFLD的发生发展中起着重要作用,有研究报道[7,8],脂联素可通过减少脂质合成,增加脂肪酸氧化,减少肝脏脂质含量。本研究,
李琪, 王晓峰
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Phenotype-genotype correlation in β-thalassemia
Thalassemia Reports, 2011 The clinical manifestations of β-thalassemia are extremely heterogeneous, ranging from severe transfusion-dependent anemia, to the mild non transfusion dependent thalassemia intermedia and to the asymptomatic carrier state. The remarkable phenotypic
R. Galanello +4 more
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, 2016 2002-2003 > Academic research: refereed > Publication in refereed journalVersion of ...
Qian, ZM, Wen, ZM
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Research progress in the relationship between iron deficiency and tic disorder [PDF]
Tic disorder is a common neurodevelopmental disorder disease in children， with a high prevalence and different clinical manifestations among individuals.
Wang Yun, Xiang Jingjing, Zheng Qian, Bai Jinxiu
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Toxicological effects of BaP or Aroclor1254 on the embryos and fries of Pagrus major and Lateolabrax japonicus [PDF]
, 2006 迄今研究证明，hepcidin的诱导表达与病原菌感染或者铁代谢调节有关，有机污染物是否可以诱导hepcidinmRNA的表达尚未见报道。而鱼类P4501A基因的诱导表达已被作为暴露于持久性有机污染物的早期预警信号。本文以持久性有机污染物的代表BaP和Aroclor1254为受试物，以海水养殖花鲈和真鲷的胚胎和仔鱼为实验材料。观察了不同Aroclor1254浓度、不同时间处理下的胚胎形态学变化。进一步用分子生物学方法研究了与污染物诱导相关P4501A和hepcidin基因的表达变化。实验获得了如下结果 ...
黄叔卓
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Zhongguo shiyan zhenduanxue, 2016 目的探讨缺铁性贫血对不同基因型α地中海贫血筛查的影响,评估HbA2与红细胞各指标在鉴别缺铁性贫血和各种基因型α地中海贫血中的作用。方法严格筛选正常人群样本、α地中海贫血患者样本、缺铁性贫血患者样本和α地中海贫血合并缺铁性贫血患者样本,进行血红蛋白电泳、血常规、铁蛋白和地中海贫血基因诊断,统计分析不同检测指标在各样本组差异。结果缺铁性贫血的HbA2平均水平低于α地中海贫血,HbH病患者HbA2水平低于缺铁性贫血。鉴别正常人群和单纯α地中海贫血时,MCH比MCV有更高的敏感性。鉴别α地中海贫血和缺铁性贫血时,
陈卫东, 周宇, 王秋
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Protective effect of dihydromyricetin against hippocampal neuronal injury caused by iron overload and its mechanism [PDF]
Objective To investigate the protective effect of dihydromyricetin (DMY) against injury of primary hip-pocampal neurons caused by ferric ammonium citrate (FAC) and its mechanism.
SUI Yunjie, MA Zegang
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Zhongshan Daxue xuebao. Yixue kexue ban铁与高血压的关系近年来已成为心血管领域的重要前沿方向。铁死亡（ferroptosis）作为近年发现的一种铁依赖性细胞死亡形式，已被证实在多数心血管疾病及其相关疾病的发生发展中扮演着十分重要的角色。铁死亡的核心机制涉及铁代谢紊乱、脂质过氧化反应以及抗氧化系统的损伤，这些机制在高血压的病理进程中起着重要作用。铁死亡中铁代谢失衡和脂质过氧化这两者是导致高血压疾病相关血管损伤、血管重构以及高血压靶器官损害的关键因素。本文系统梳理了铁死亡与高血压之间的分子关联及其病理生理机制网络，重点探讨了铁死亡中铁代谢紊乱 ...
刘琪悦, 刘丽军
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野生动物学报, 2008 目的:通过对9只来自野外和园内养大的云豹毛中锌、铜、铁、钙4种元素检测,了解云豹对这4种元素代谢特点与产生脱毛症的关系。方法:从云豹尾部的上1/3处采毛,用原子吸收光谱法检测。结果:在所检测的9只云豹中,其中3只患脱毛症的云豹毛中铜元素含量都低于4.4μg/g,其他3种元素所测结果表明与脱毛症均没有直接关系。结论:铜元素缺乏可能与云豹患脱毛症关系密切。
马再玉 +3 more
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