, 2007 为了鉴定柱状黄杆菌(Flavobacterium columnare)的毒力相关因子,利用蛋白质组学方法分析了强毒株G4R3和弱毒株G18的外膜蛋白。双向电泳结合图像分析,共发现了8个差异表达的蛋白点。经过胶内酶解和质谱分析,其中的1个蛋白点被鉴定为LemA蛋白 ...
聂品, 刘国勇, 陈发菊
core
, 2007 本发明涉及动物血液的开发利用，一种珠蛋白酶解物，其以猪血中的血红蛋白脱除血红素后得到的珠蛋白为原料，通过加蛋白酶酶解的方法，制成富含活性肽的蛋白酶解物。该酶解物具有显著抑制血管紧张素I转换酶活性的作用，可用于治疗和预防高血压，同时具有增强机体防御功能、调节生理节律、预防疾病和促进康复等作用 ...
余奕珂 +5 more
core
[Mechanism of mesenchymal stem cell-derived exosomes in alleviating hypoxia/re-oxygenation-induced injury of oligodendrocytes]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiMeng YC, Wang C, Zhu YP.
europepmc +1 more source
[Gastrodin alleviates hypobaric hypoxia-induced brain injury in rats by reducing neuronal ferroptosis <i>via</i> the P53/SLC7A11/GPX4 signaling axis]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoYang J +7 more
europepmc +1 more source
[Chronic iron overload induces diminished ovarian reserve in mice <i>via</i> iron metabolism dysregulation-mediated oxidative stress and endocrine dysfunction]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoYu J, Chu J, Liang C.
europepmc +1 more source
EGCG调控AMPK/GSK-3β/Nrf2抑制铁死亡减轻阿霉素诱导的心脏毒性
Zhongguo shiyan zhenduanxue目的探究表没食子儿茶素没食子酸酯（EGCG）是否通过AMPK/GSK-3β/Nrf2信号通路抑制铁死亡，从而减轻阿霉素心脏毒性。方法建立阿霉素心肌损伤模型，将C57BL/6J小鼠随机分为3组：Control组、DOX组、DOX+EGCG组。HE染色观察心肌形态学变化，试剂盒检测心肌组织丙二醛（MDA）和铁离子（Fe2+）含量。免疫荧光检测活性氧（ROS）水平。Western blot检测AMPK、GSK3β、Nrf2蛋白表达。建立H9C2心肌细胞阿霉素损伤模型。实验分为5组：Control组、DOX组 ...
韩必成 +3 more
doaj
[Advances in the molecular genetics of nuclear gene mutations causing pediatric mitochondrial cardiomyopathy]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiWang ZW, Wang YQ, Wang CL.
europepmc +1 more source
[Role of programmed cell death in platinum resistance in ovarian cancer]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanXu J, Zhou X, Luo C.
europepmc +1 more source
[SENP1 reduces ferroptosis of thyroid cancer cells by regulating hypoxia-inducible factor-1α]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhu F, Yan N, Yang J, Chen X, Wang Y.
europepmc +1 more source
[Inhibition of ferroptosis by geniposide via activation of the SIRT3 signaling pathway to alleviate inflammatory injury in endothelial cells]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiSun WT, Zhao MM, Shi ZL.
europepmc +1 more source