Results 1 to 10 of about 198 (106)
中西医结合护理, 2022 This paper summarized the nursing management of pressure ulcers in a patient with diabetes and Alzheimer‘s disease. In addition to routine care for pressure ulcers, efforts were made to enhance the skin hygiene and wound care.
ZHANG Yixuan (张艺璇) +6 more
doaj +1 more source
Human Health Risks of Artificial Sweeteners(人造甜味剂与人体健康风险) [PDF]
Shipin kexue jishu xuebao, 2018 Artificial sweeteners (AS) are favored by food manufacturing markets and consumers due to their high sweetness, low prices and low calories. At present, 9 kinds of AS are approved in more than 10 categories of food and beverages in China.
ZHAO Hui(赵辉) +1 more
doaj +1 more source
Interpretation of US cancer statistics 2023 and its implications for cancer prevention and treatment in China [PDF]
, 2023 In the year 2023, 1 958 310 new cancer cases and 609 820 cancer deaths are projected to occur in the United States, estimated by Cancer Statistics, published by American Cancer Society.
ZHOU Changming, WANG Zezhou, ZHENG Ying
core +1 more source
Zhongguo shiyan zhenduanxue, 2023 帕金森病(Parkinson’s disease, PD)作为仅次于阿尔兹海默病的全球第二常见的神经退行性疾病，其发病率呈逐年上升趋势。根据2015年全球疾病负担估计，PD病例数量在未来仍会快速增长，二十年内患者总数将突破千万，这将给社会和家庭带来巨大负担和伤害。与此同时，帕金森病早期临床症状不典型居多，多数患者确诊时，病情已经较为严重，体内的黑质多巴胺严重缺乏，
吕璇 +4 more
doaj
Relationship of Cognitive Function with Emotion and Sleep Architecture in Patients with OSAHS [PDF]
, 2022 Background Obstructive sleep apnea-hypopnea syndrome （OSAHS） is a sleep-related breathing disease，which influences patients' sleep quality and emotion regulation due to long-term intermittent hypoxemia and sleep fragmentation.
LIU Yishu, TAN Huiwen, ZENG Yin, XIAO Li
core +1 more source
Zhongguo shiyan zhenduanxue, 2022 阿尔茨海默病( Alzheimer’s disease, AD)是一种起病隐匿的神经系统退行性疾病。95%～99%的AD患者没有家族遗传史，这称为散发性AD。随着年龄的增长，AD发病的风险呈指数级增加。WHO最新报告统计，全世界有近3560万人患有痴呆症。当前，中国的AD患者已超过1000万人，是新发病例全球增速最快的国家之一。AD的病因迄今未明，涉及多种因素的综合作用，如遗传因素、环境因素、免疫因素、生活方式等[1]。
侯雪佳, 孙鸽, 纳涛, 姜金兰
doaj
微小RNA628-5p/Tyrobp对阿尔兹海默病潜在的诊断和治疗价值
Zhongguo shiyan zhenduanxue, 2021 阿尔茨海默病（AD）是一种严重的神经退行性疾病,并伴有进行性认知功能下降,其发病机制复杂,已经成为了一个全球性的公共健康问题[1]。目前淀粉样蛋白假说是被广泛接受的AD发病机制之一[2],β-淀粉样肽（Aβ）在人脑细胞中的持续积累是AD的核心病理改变。许多抑制Aβ的产生和促进Aβ分解的药物被相继开发出来,然而随着这些靶向药物在三期临床试验中的失败[3],寻找AD新的分子机制变得非常必要,这将有利于对AD的诊断以及新的靶点药物的研发。
张瑜, 吕周艳, 李艳冰, 王蕾蕾
doaj
Advances on mechanisms of regulated cell death in neurotoxicity of aluminum [PDF]
, 2023 Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on
Guangzi QI +6 more
core +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探究丙烯醛是否能够诱发体内外发生铁死亡现象。方法体外：给予小鼠海马神经元细胞系HT22细胞丙烯醛进行造模，采用铁死亡抑制剂铁抑素-1（Fer-1）与去铁胺（DFO）进行保护。MTT法检测细胞存活率；自由基探针二氢乙啶（DHE）与亚铁探针FerroOrange检测细胞内自由基与亚铁离子含量；透射电镜观察正常与模型组的线粒体超微形态与结构；Western blot法检测铁死亡相关蛋白表达的情况。体内：雄性C57BL/6小鼠，7~8周龄每日给予3 mg/kg的丙烯醛分别进行造模1、2、4周 ...
彭伟嘉 +4 more
doaj
高脂饮食诱导
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨高脂饮食引起的慢性炎症反应与阿尔兹海默病神经功能障碍之间的关系。方法12月龄C57BL/6J小鼠和APPswe/PS1ΔE9（APP/PS1）雄性小鼠，按体质量随机分为4组，正常组（C57BL/6J小鼠n=6）、普通高脂组（C57BL/6J小鼠+高脂饲料n=6）、痴呆组（APP/PS1小鼠n=6）、痴呆高脂组（APP/PS1小鼠+高脂饲料n=6）4组；普通饲料/高脂饲料喂养6周。每周监测小鼠体质量变化，免疫组化观察海马小胶质细胞激活情况，RT-qPCR检测海马炎性因子IL-1β、IL-6、TNF-
李泽 +6 more
doaj