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Zhongshan Daxue xuebao. Yixue kexue ban阿尔茨海默病（AD）是老年性痴呆症中最常见的形式，其发病机制仍不清楚，但β淀粉样蛋白（Aβ）被认为是引起AD发病的重要原因，然而其引发AD的病理机制同样存在多种争议。最近研究显示，髓系细胞触发受体（TREM2）在AD病理进程中扮演重要角色，其不仅可以作为Aβ内化的重要受体，还可能成为生物学诊断标志物和治疗靶点，阐明TREM2的结构和功能，将为AD的防治提供重要的思路。本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述 ...
代玉婷, 石镜明
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氧化应激在阿尔茨海默病病理发生中的作用机制与干预策略 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 阿尔茨海默病（AD）是常见的神经变性病，氧化应激在AD 早期病理发生和发展中起到了重要的作用。在老化、早老素 1（PS1）突变及环境等共同作用下，脑内出现过度氧化应激，促进β-淀粉样蛋白（Aβ）的形成，Aβ可能为氧化应激作用下的适应性产物。氧自由基产生与清除的失衡还可导致海马神经元自噬功能异常，诱导细胞从自噬到死亡，其可能的机制是Notch1 通路失调。Notch1 通路的失调导致机体抗氧化应激能力丧失和淀粉样前体蛋白（APP）剪切增多、Aβ沉积，最终引起AD 病理的发生与发展 ...
刘军
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中西医结合护理, 2022 This paper summarized the nursing management of pressure ulcers in a patient with diabetes and Alzheimer‘s disease. In addition to routine care for pressure ulcers, efforts were made to enhance the skin hygiene and wound care.
ZHANG Yixuan (张艺璇) +6 more
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Effect of type 2 diabetes on A disintegrin and metalloprotease 10 2型糖尿病对解整合素金属蛋白酶10表达的影响
Journal of Diabetes, Volume 14, Issue 6, Page 394-400, June 2022., 2022 Highlights a disintegrin and metalloprotease 10 (ADAM10), a sheddase responsible for the cleavage of a variety of cell surface molecules, has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and inflammatory and neoplastic disorders, and systemic ADAM10 concentration may potentially be used as a prognostic biomarker. Our study
Sum Lam +3 more
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中西医结合护理, 2021 Objective To observe the effect of the Baduaniin for the elderly based on the meridian theory combined with the Intelligent Elderly Comprehensive Assessment on the cognitive function of patients with early-stage Alzheimer's disease.
CHENG Yao (程瑶) +2 more
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Changes in serum Th17/Treg-related cytokine levels in periodontitis patients with Alzheimer′s disease [PDF]
, 2023 Objective·To observe the role of serum Th17/Treg levels in the correlation between Alzheimer′s disease and periodontitis.Methods·Eighteen periodontitis patients with Alzheimer′s disease who visited the Department of Geriatric, Shanghai Mental Health ...
QIU Che +4 more
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, 2018 从PM2.5对阿尔茨海默病的标志物、炎症、脑的发育及其他因素造成的影响等方面入手,综合阐述了PM2.5与阿尔茨海默病之间的联系。PM2.5引发阿尔茨海默病的机制尚不明确,我们推测PM2.5导致的阿尔茨海默病的标志物增多、炎症反应及氧化损伤等可能是引发该病的重要原因。中国博士后科学基金面上资助项目 ...
王娜, 钟力, 魏敏
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Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
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基于显著性信息的Fit CutMix数据增强算法在医学影像上的应用
智能科学与技术学报, 2023 深度卷积神经网络是图像分类领域的主流算法之一，但是其训练需要大量标注数据，在阿尔茨海默病医学影像等小数据集上易出现过拟合现象。数据增强算法可以用于扩充数据量，其中 CutMix 数据增强算法近来被广泛应用，但是现有方法生成的增强图像往往忽略原始图像显著区域，且增强图像的标签设计考虑的因素较为单一。针对这些问题，提出Fit CutMix数据增强算法。该算法一是利用基于显著性极值迁移的区域替换策略生成增强样本，集中源样本与目标样本中显著性高的区域；二是综合源样本与目标样本的面积和显著性信息赋予增强样本标签 ...
罗欣欢, 王奕璇, 李炜, 陈曦
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Effect of Partially Hydrolyzed Guar Gum on Learning and Memory Ability of Alzheimer's Disease Mice(部分水解瓜尔豆胶对阿尔茨海默病小鼠学习记忆能力的作用) [PDF]
Shipin kexue jishu xuebao, 2023 To study the effect of partially hydrolyzed guar gum (PHGG) on learning and memory ability of APP/PS1 Alzheimer's disease (AD) mice, PHGG dietary intervention was taken by APP/PS1 mice for 3 months, and the learning and memory ability was measured by ...
LI Tao(李涛) +5 more
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