Results 11 to 20 of about 4,596 (150)
Zhongguo shiyan zhenduanxue, 2009 目的探明非小细胞肺癌细胞株H1975的水通道AQP1表达情况,以探讨水通道AQP1作为非小细胞肺癌治疗靶位的可能性。方法培养非小细胞肺癌细胞株H1975,应用RT-PCR及Western Blot等方法检测水通道AQP1的表达情况。结果两种方法均证实了非小细胞肺癌细胞株H1975表达水通道AQP1。结论非小细胞肺癌细胞株H1975高表达水通道AQP1,提示AQP1可能在非小细胞肺癌的增殖、转移中起重要作用,AQP1可能成为治疗在非小细胞肺癌新的分子靶点。
毕林涛 +5 more
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Plasma microRNA Associated with EGFR-TKI Primary Resistance in Non-Small Cell Lung Cancer with EGFR-Mutation [PDF]
, 2016 背景 肺癌是目前全世界范围内发病率和死亡率较高的恶性肿瘤之一。按组织学分类，肺癌可以分为两大类：小细胞肺癌（smallcelllungcancer，SCLC）和非小细胞肺癌（nonsmallcelllungcancer，NSCLC），小细胞肺癌占所有病例的20%，其余80%左右为NSCLC，包括鳞癌、腺癌、大细胞癌等类型。手术、放疗以及化疗等多学科综合治疗是指南推荐的NSCLC的首选治疗方式。由于NSCLC早期的典型临床症状和体征并不明显，约2/3的NSCLC患者在确诊时已发展为中晚期，失去手术根治机会。
潘小艳
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Zhongguo shiyan zhenduanxue, 2017 肺癌（lung cancer,LC）包括非小细胞肺癌（non-small cell lung,NSCLC）和小细胞肺癌（SCLC）,其中非小细胞肺癌（鳞癌、腺癌和大细胞未分化癌）占肺癌的80%以上[1]。非小细胞肺癌按照TNM分期,临床上根据不同的病理分期采用相应的治疗方案 ...
刘一婷 +4 more
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Clinical Application of Adjuvant Treatment after Operation in Patients with Stage IIIa Non-small Cell Lung Cancer [PDF]
, 2010 Background and objective The efficacy of complete resection of the cancer for patients with stage IIIa non-small cell lung cancer (NSCLC) is limited. Synthetic therapy is taken the lead in advocating at present.
Bin ZHANG, Xia ZHANG, Yajie GAO
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Zhongguo shiyan zhenduanxue, 2013 目的探讨β连环素（β-catenin）和MMP-2在非小细胞肺癌中的表达及意义。方法采用免疫组织化学方法检测39例肺癌组织及8例正常对照肺组织中β-catenin和MMP-2的表达,并结合临床和病理资料进行分析。结果 1.β-catenin和MMP-2在非小细胞肺癌组织中的胞质表达明显高于对照组,差异具有显著性 ...
孔康宝, 李光虎, 杨波, 崔永生
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Study on the Molecular Mechanisms of dlk1 Stimulated Lung Cancer Cell Proliferation [PDF]
, 2010 Background and objective The imprinted gene dlk1 has been recognized as a cancer related gene since it aberrantly expressed in a series of cancer tissues, but its role in lung cancer is still unknown. The aim of this study is to examine dlk1’s expression
Bing LING +10 more
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A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC [PDF]
, 2009 Background and objective Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (
Kai TANG +4 more
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Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Cisplatin-based Chemotherapy [PDF]
, 2010 Background and objective Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting.
Hui ZHANG +6 more
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Zhongguo shiyan zhenduanxue, 1998 目的探讨蛋白质磷酸化酶抑制剂对肺癌细胞株的增殖抑制作用。方法用蛋白质磷酸化酶抑制剂对６株小细胞肺癌和７株非小细胞肺癌细胞株的增殖抑制效果进行了检测，并采用免疫法，测定了蛋白质磷酸化酶抑制剂对肺癌细胞内Ｒｂ蛋白表达的影响。结果随其浓度的增加，对肺癌细胞株的增殖抑制作用增强，小细胞肺癌的半数抑制量平均值ＳＴ为９５ｎＭ，ＵＣＮ－０１为５８８ｎＭ，非小细胞肺癌则分别为１８８ｎＭ和１０２９ｎＭ，ＳＴ和ＵＣＮ－０１可抑制肺癌细胞Ｒｂ蛋白的磷酸化。结论蛋白质磷酸化酶抑制剂通过抑制Ｒｂ蛋白的磷酸化 ...
赵美蓉, 王杨, 裴瑞莲
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Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer [PDF]
, 2011 Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer ...
Boshi WANG +7 more
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