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Effect and mechanism of microRNAs on various diabetic wound local cells microRNA对各种糖尿病创面局部细胞的作用及机制
Journal of Diabetes, Volume 15, Issue 11, Page 955-967, November 2023., 2023 Highlights For the first time, we have examined the impact of microRNA on diabetic wounds at a cellular level. We have analyzed how a particular microRNA influences different types of cells, uncovering its function and mechanism. This study furthers the discovery of the clinical potential of diverse microRNAs by evaluating their distinct effects and ...
Hongjie Li, Shengyu Jing, Hongbo Xu
wiley +1 more source
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
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Research progress of immune response regulated by epigenetic modification in pneumonia [PDF]
, 2023 Pneumonia is one of the most common infectious diseases, and although considerable progress has been made in the diagnosis and treatment of pneumonia, it is still associated with high mortality, prolonged hospitalization, and significant medical ...
HAN Xiao, WANG Qing, ZHANG Xiaobo
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Construction and validation of prognostic risk model for hepatocellular carcinoma based on biological analysis of palmitoyl-associated enzyme long-chain non-coding RNA [PDF]
, 2023 Objective·To explore the effect of screening the expression of long non-coding RNA (lncRNA) related to palmitoylation on prognosis of liver cancer based on The Cancer Genome Atlas (TCGA) database and construct a risk prediction model in liver cancer ...
LI Yahui +4 more
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Zhongguo shiyan zhenduanxue, 2022 长链非编码 RNA(Long non-coding RNA,LncRNA)位于细胞质或细胞核中，长度超过200nt，是一类非编码 RNA 分子，可通过结合表观遗传蛋白修饰其靶基因；与 mRNA 碱基互补结合，抑制翻译和降解；作为ceRNA 竞争性结合 microRNA 等方式调控基因的表达，参与调节机体的各项生命活动[1-2]。
钟剑锋, 钟莉莉, 于双
doaj
Effect of dynamic interaction between microRNA and transcription factor on gene expression [PDF]
, 2016 MicroRNA(miRNA)是内生的非编码RNA，通常涉及动物和植物不同的生物过程。它们与转录因子和下游基因相互作用，形成复杂并且高度关联的调控网络。为了认识一些发挥重要基础调控作用的代表性模块，我们构建了一个包含miRNA的前馈环路模型，该模型包含转录因子调控miRNA和目标基因。根据miRNA和转录因子对基因表达不同的相互作用关系，四种可能的前馈环路结构与两类gate函数被引入。当转录因子的生成率是常数时，我们发现除了Co1环路外，其它模块中的目标基因水平都表现出脉冲行为。进一步 ...
赵琪
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TGF-β1/SMAD在糖尿病肾病中的作用机制与研究进展 [PDF]
, 2023 Diabetic nephropathy (DN) is a common complication of diabetes and a leading cause of end-stage renal disease. Transforming growth factor-β1 (TGF-β1)/SMAD signaling activation plays an important role in the onset and progression of DN.
Chen, Haiyong +4 more
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Zhongguo shiyan zhenduanxue, 2020 近年来随着对非编码RNA(noncoding RNAs,ncRNAs)研究的深入,发现非编码RNA,比如miRNAs、piRNAs以及circRNAs,在各类疾病发生、进展以及治疗等方面都有重要作用[1]。最近,一类来源于tRNA的小的非编码RNA逐渐引起广泛关注[2]。在真核细胞的细胞核中,tRNA被RNA聚合酶Ⅲ转录,转录在tRNA成熟序列3′端下游10-60nt处延伸了四个或多个Ts后终止[3 ...
赵敏 +7 more
doaj
Expression and biological behaviors of long non-coding RNA-ROR in gastric cancer [PDF]
, 2016 背景：胃癌是消化系统常见的恶性肿瘤，发病率高，预后效果差。早期发现、早期诊断是目前提高胃癌患者生存率的关键环节，因此，寻找新的胃癌早期诊断的分子标志物是目前胃癌研究亟待解决的问题之一；此外，近年来肿瘤的分子靶向治疗方兴未艾，但这些靶向治疗药物价格昂贵、疗效不稳且大多依赖进口，因而，从我国国情的实际出发，寻找新的治疗靶点是我国目前肿瘤靶向治疗急需克服的困难。长链非编码RNA-ROR是最新发现对细胞重编程过程具有重要调控作用的非编码RNA。目前研究发现ROR与乳腺癌、肝癌及胶质瘤的发生进展密切相关 ...
朱长明
core
New Phytologist, Volume 247, Issue 2, Page 504-517, July 2025.Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sridevi Sureshkumar +3 more
wiley +1 more source