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Liu Y, Li C, Han Y.
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Shang YL, Han Y.
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Lin W +6 more
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Yuan XT, Wang L, Chen LX, Hu LH.
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Zhao X +8 more
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Chen M, Huang R, Yang Z.
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Zhao D, Hsieh C.
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目的 探究20种常见氨基酸在结直肠癌(CRC)患者的尿液特征;寻找CRC诊断的生物学标志物。方法 纳入100名健康对照者和113名CRC患者(Ⅰ期27例,Ⅱ期28例,Ⅲ期34例,Ⅳ期24例),基于超高效液相色谱串联质谱法对尿液中的20种常见氨基酸应用多反应监测技术进行靶向定量分析,应用统计学方法分析CRC患者与健康对照氨基酸含量差异,并构建CRC诊断模型。结果 CRC患者尿液中16种氨基酸含量与健康对照差异有统计学意义,Ⅰ,Ⅱ,Ⅲ和Ⅳ期各自有9种,15种,14种 ...
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