Results 91 to 100 of about 31,599 (213)
Research of TTA1,Tat,PEG modified gelatin-siloxane combined with siRNA transfecting C6 cells and inhibiting its EGFR gene expression [PDF]
, 2016 背景：脑胶质瘤是颅内最常见的恶性肿瘤，其预后差，治疗效果不佳，患者平均生存期短一直是世界性难题。近年来，随着现代医学和分子生物学的发展，基因治疗广受医学界的关注。RNA干扰（RNAi）是目前极具前景的脑胶质瘤基因治疗手段之一。脑胶质瘤基因治疗的关键因素之一在于基因载体系统。理想的基因载体系统，应具有能够穿透血脑屏障的能力、较高的基因转染效率、良好的胶质瘤细胞靶向性和生物相容性以及较高的稳定性和安全性等优点。本课题以明胶硅氧烷纳米粒子（GSNPs）修饰上亲水性聚乙二醇（PEG ...
胡洋
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A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC [PDF]
, 2009 Background and objective Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (
Kai TANG +4 more
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Analysis of Differentially Expressed Proteins in Self-Paired Sera of Advanced Non-small Cell Lung Cancer Patients Responsive to Gefin [PDF]
, 2009 Background and objective All the advanced NSCLC patients that received EGFR-TKI therapy will eventually relapse after a period of efficacy. The aim of this study is to investigate the serum biomarkers as potential predictive factors for the efficacy of ...
Ailin GUO +10 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨实时二维剪切波弹性成像（2D SWE）评估慢加急性乙型肝炎肝衰竭（ACLF-HBV）患者预后的临床 应用价值。【方法】入组对象为2013年10月1日至2015年12月31日我院感染科确诊的312例慢加急性乙型肝炎肝衰竭患 者。观察终点为90 d，根据临床结局分为好转组192例和恶化组120例。入组后3 d内，应用2D SWE进行肝脏硬度测量， 收集患者血常规、凝血、生化等血清学指标，观察患者肝实质回声均匀度、肝包膜光滑度、右肝厚度、胆囊壁厚度、脾脏指 数、腹水指数、门静脉主干内径 ...
金洁玚 +5 more
doaj
Immediate Versus Delayed Topotecan after First-line Therapy in Small Cell Lung Cancer [PDF]
, 2010 Background and objective How to prolong progression free survival (PFS) and overall survival (OS) of patients with small cell lung cancer (SCLC) has been one of the hottest issues. We retrospectively reviewed our data to compare the survival of immediate
Cong XUE +7 more
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症状性大脑中动脉M1段重度狭窄/闭塞患者磁共振血流信号与短期预后的关系
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 【目的】探讨症状性大脑中动脉（MCA）M1段重度狭窄和闭塞患者三维时间飞跃法磁共振血管成像 （3D-TOF-MRA）上血流信号与短期预后的关系。【方法】回顾性连续纳入2009年5月至2016年5月入院的症状 性MCA-M1段重度狭窄和闭塞患者。收集患者的一般信息、临床资料和头颅影像学数据。分析患者在3D-TOF- MRA上血流信号特点，包括：（1）MCA病变远端血流信号；（2）大脑后动脉（PCA）偏侧化。分析MCA-M1段重度 狭窄和闭塞患者3D-TOF-MRA上血流信号特点与短期预后的关系 ...
束礼明 +4 more
doaj
Extraction and identification of urine derived stem cells and its effect on adriamycin induced nephropathy in mice [PDF]
, 2016 中文摘要 目的1、提取分离和培养尿源性干细胞(USCs urine-derivedstemcells)，并鉴定其相关生物学特性。 2、通过静脉注射盐酸阿霉素建立阿霉素肾病小鼠模型。 3、通过肾组织病理观察，检测生化，应用Westernblot技术观察USCs移植和胚胎干细胞治疗保护小鼠阿霉素肾病的效果，并对尿源性干细胞在阿霉素肾病小鼠中保护作用及相关机制进行探讨。 方法1、小鼠尿源性干细胞(USCs）的提取、分离、培养与鉴定:通过收集人尿液分离出尿源性干细胞，利用离心沉淀方法分离培养，体外纯化、传代 ...
孟昕
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