摘 要:【目的】 探讨曲美他嗪对链佐菌素诱导的1型糖尿病大鼠心肌组织肿瘤坏死因子-α(TNF-α)和超氧化物歧化酶-2(SOD-2)蛋白表达?心肌组织氧化应激水平及心脏功能的影响?【方法】 选用6周龄雄性SD大鼠30只,随机分为3组:正常对照组(N组);糖尿病对照组(10只,C组);糖尿病联合曲美他嗪干预组(TMZ:15 mg·kg-1·d-1;N = 10,TMZ组)?将链佐菌素溶解于0.1 mol/L柠檬酸缓冲液中,以40 mg·kg-1剂量腹腔注射大鼠,诱导1型糖尿病大鼠模型?TMZ组以曲美他嗪 ...
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