Research progress on the role of zinc finger proteins in the development of oral cancer [PDF]
Oral cancer is one of the most common malignancies in the head and neck regions. few patients benefit from current clinical therapy. Zinc finger proteins (ZNFs) are one of the largest transcription factor family proteins in the human genome. ZNFs bind to
SI Hang, FENG Yan, YU Li
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A study on communication mechanism of lung cancer cells in tumor microenvironment mediated by pleckstrin-2/miR-196a signal axis [PDF]
Background and purpose: It is still a great challenge to clarify the signal molecules that mediate the communication between cancer-associated fibroblasts (CAFs) and tumor cells. These signal molecules are very important for cancer metastasis.
WANG Manli, CHEN Hui, DUAN Zhi, XU Qimei, LI Zhen
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消化系统早癌与神经内分泌肿瘤——浅谈常见病与罕见病的关系 [PDF]
本文聚焦于神经内分泌肿瘤与消化系统早癌，探讨罕见病与常见病之间的关系。以神经内分泌肿瘤与消化系统早癌为切入点，通过比较两者在临床表现、内镜下表现、生物学行为及临床转归等方面的异同，揭示罕见病和常见病的潜在关联。本文旨在深化对这两类疾病的认识，提升神经内分泌肿瘤等罕见病的检出率，推动其精准诊断，从而为早期干预和治疗创造更多机会 ...
施慧英, 蔺蓉
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Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 [PDF]
Objective To construct a molecular classification system for head and neck squamous cell carcinoma (HNSCC) utilizing hypoxia-related gene (HAG) expression profiles, and to comprehensively examine the clinicopathological significance and biological ...
ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan
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Computed Tomography Radiomics to Preoperatively Predict Regional Lymph Node Metastasis of Resectable Adenocarcinoma of the Esophagogastric Junction [PDF]
Objective: To construct and validate computed tomography (CT) radiomics models to preoperatively predict regional lymph node (LN) status of resectable adenocarcinoma of the esophagogastric junction (AEG).
Hui LUO +7 more
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Cost-effectiveness of PD-L1 testing to guide immunotherapy for patients with non-small cell lung cancer in China [PDF]
Background and purpose: According to the latest data from the National Cancer Center, the incidence rate and mortality of lung cancer in China rank first among all malignant tumors, and 85% are non-small cell lung cancer (NSCLC).
LI Yuan, GUO Lingchuan, YUAN Yong, ZHENG Qiang, JIN Yan, MING Jian
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异类叶升麻苷调控PI3K/Akt/mTOR通路抑制人食管鳞状癌ECA109细胞增殖及迁移的机制研究
Zhongguo shiyan zhenduanxue目的探究异类叶升麻苷基于PI3K/Akt/mTOR信号通路抑制人食管鳞状癌ECA109细胞增殖及迁移的作用机制。方法采用不同浓度异类叶升麻苷处理ECA109细胞，通过CCK-8与克隆形成实验评估细胞增殖活性；根据CCK-8检测结果分为对照组和异类叶升麻苷低（150 μM）、中（300 μM）和高（400 μM）剂量组，通过划痕愈合实验评估细胞迁移能力，Western blot检测细胞PI3K p85、p-PI3K、Akt、p-Akt、mTOR、p-mTOR 蛋白表达及磷酸化水平，RT ...
宋文潇 +4 more
doaj
血浆外泌体LncRNA POU3F3与SCCA联合检测对食管鳞癌早期诊断及淋巴结转移风险预测的价值
Zhongguo shiyan zhenduanxue目的探讨血浆外泌体长链非编码RNA 八聚体结合蛋白3（LncRNA POU3F3）与鳞状细胞癌抗原（SCCA）单项及联合检测在食管鳞状细胞癌（ESCC）早期诊断和淋巴结转移（LNM）风险预测中的临床价值。方法选取120例ESCC患者（其中淋巴结转移组68例，无转移组52例）和60例健康体检者。采用RTq-PCR技术检测血浆外泌体中LncRNA POU3F3的表达水平，化学发光法检测血浆SCCA浓度。通过受试者工作特征（ROC）曲线评估各指标及联合检测的诊断与预测效能。结果ESCC组血浆外泌体lncRNA
张军伟 +3 more
doaj
[LINC00261 suppresses esophageal squamous cell carcinoma proliferation, invasion, and metastasis by targeting the miR-23a-3p/ZNF292 axis]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoMi Y +6 more
europepmc +1 more source
[High expression of the stemness-associated molecule Nanog in esophageal squamous cell carcinoma tissues promotes tumor invasion and metastasis by activating the TGF-β signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoSun C +11 more
europepmc +1 more source