Results 211 to 220 of about 25,862,707 (267)

Frailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis. [PDF]

J Cachexia Sarcopenia Muscle
Kremer WM, Schwarz A, Dumont MC, Gairing SJ, Sivanathan V, Galle PR, Sprinzl MF, Schleicher EM, Labenz C.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A Rapid Systematic Review of AI-Generated and Human-Generated Real-Time Feedback in Nursing Education. [PDF]

Int Nurs Rev
Rajasekaran R, Attawet J, Bhandari P, Thomas M, Qiu Y.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor-Selective Deficits. [PDF]

Glia
Bloom AJ, Tendulkar S, Hackett AR, Strickland A, Sato-Yamada Y, Yuan L, Dong W, Ippolito J, Schmidt RE, Sasaki Y, DiAntonio A, Milbrandt J.   +11 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Studying multiracial adolescents' racial self-categorization(s): Conceptual, methodological, and analytic recommendations. [PDF]

J Res Adolesc
Vezaldenos V, Grogan-Kaylor A, Rivas-Drake D.   +2 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Multi-Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single-Trait GWAS. [PDF]

Genet Epidemiol
Ma Y, Argoty-Pantoja AD, Xie T, Barnes MR, Munroe PB, Cabrera CP, Snieder H, Warren HR, UMCG Genetics Lifelines Initiative (UGLI) group author: LifeLines Cohort Study.   +8 more
europepmc   +1 more source

Predictive Contribution of Clinical Measures of Ankle Neuromuscular Impairments to Ankle Kinematic Deviations During Gait in Children With Cerebral Palsy. [PDF]

J Foot Ankle Res
Manikowska F, Brazevic S, Chen BP, Jóźwiak M, Lebiedowska MK.   +4 more
europepmc   +1 more source