Results 51 to 60 of about 331,479,482 (252)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

On Hardy kernels as reproducing kernels

open access: yesCanadian Mathematical Bulletin, 2022
AbstractHardy kernels are a useful tool to define integral operators on Hilbertian spaces like $L^2(\mathbb R^+)$ or $H^2(\mathbb C^+)$ . These kernels entail an algebraic $L^1$ -structure which is used in this work to study the range spaces of those operators as reproducing kernel Hilbert spaces. We obtain their reproducing kernels, which in the $
openaire   +4 more sources

Technical dynamic capabilities in the opinion of Polish producers from the agricultural machines sector1

open access: yesManagement, 2018
The main aim of this paper is to develop a model of key technical dynamic capabilities providing implementation flexibility of manufacturing companies of the Polish agricultural sector.
Nogalski Bogdan   +2 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Exploring the Relationship of Ethical Leadership with Job Satisfaction, Organizational Commitment, and Organizational Citizenship Behavior [PDF]

open access: yes, 2014
The impact of ethics on recent leadership practices has assumed a prominent role in both practical and theoretical discussions of organizational leadership successes and failures.
Yates, Laurie A.
core   +1 more source

Simplified modelling of the performance of concrete tunnels during fire and post-fire damage classification

open access: yesActa Polytechnica CTU Proceedings, 2022
The performance of concrete tunnel structures during and after fire is not well understood. This is an obstacle to the adoption of risk-based approaches for fire safety design of tunnel structures.
Ruben Van Coile   +4 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Propagation Kernels

open access: yesCoRR, 2014
We introduce propagation kernels, a general graph-kernel framework for efficiently measuring the similarity of structured data. Propagation kernels are based on monitoring how information spreads through a set of given graphs. They leverage early-stage distributions from propagation schemes such as random walks to capture structural information encoded
Marion Neumann   +3 more
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Investigating the origin of cyclical wind variability in hot, massive stars - II. Hydrodynamical simulations of co-rotating interaction regions using realistic spot parameters for the O giant $\xi$ Persei [PDF]

open access: yes, 2017
OB stars exhibit various types of spectral variability historically associated with wind structures, including the apparently ubiquitous discrete absorption components (DACs).
David-Uraz, A.   +4 more
core   +1 more source

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