Results 61 to 70 of about 2,496,017 (244)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

FX1498 npr-12(tm1498)IV | 2011-01-18T15:01:00+00:00

, 2017
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> ...
Javer, Avelino, Hokanson, Jim (5398172), Yemini, Eviatar (5398169), Grundy, Laura J, Hokanson, Jim, Kerr, Rex (5398163), Schafer, William R (5398166), Lee, Chee Wai (5398145), Brown, André EX (5398142), Ch'ng, Quee-Lim, Ch'ng, Quee-Lim (5398154), Currie, Michael (5398160), Brown, André EX, Javer, Avelino (5398151), Lee, Chee Wai, Li, Chris (5398175), Li, Kezhi, Kerr, Rex, Currie, Michael, Li, Chris, Li, Kezhi (5398157), Yemini, Eviatar, Schafer, William R, Grundy, Laura J (5398148)   +23 more
core   +1 more source

Near‐Unity Selectivity Inversion Between CO2 Electroreduction and H2 Evolution via Atomic Coordination Editing

Advanced Science, EarlyView.
Atomic coordination editing functions as an on/off switch that toggles single‐atom catalysts between CO2 electroreduction and hydrogen evolution. ABSTRACT Precise atomic coordination editing of single‐atom catalysts (SACs) provides an effective strategy to tune their electronic structures and catalytic selectivity. Yet, achieving near‐unity selectivity
Yukun Zhao, Yuanyuan He, Mengyu Duan, Peng Yin, Jinxing Chen, Xu Han, Jie Yang, Yulin Wang, Xingjie Fu, Shibo Xi, Chuncheng Chen, Jiong Lu   +11 more
wiley   +1 more source

Boosting Ferroelectricity: 2D and Polymer Ferroelectric Hybrids Enabling Ambipolar Nonvolatile MoS2 Memory Transistor

Advanced Science, EarlyView.
Two‐dimensional CuInP2S6 nanosheets are incorporated into a P(VDF‐TrFE) matrix to induce polarization‐cooperative ferroelectric coupling. The resulting P(VDF‐TrFE)/CuInP2S6 hybrid film exhibits reinforced ferroelectric ordering and reduced coercive electric fields compared with pristine P(VDF‐TrFE).
Yeonsu Jeong, Honglei Wang, Pietro Tordi, Ying Chieh Hu, Adrián Tamayo, Bing Wu, Hyun Soo Ahn, Zdenek Sofer, Jong Hoon Jung, Massimo Bonini, Paolo Samorì   +10 more
wiley   +1 more source

Dual‐Module Near‐Infrared Fluorophores Discovery System via Knowledge Transfer

Advanced Science, EarlyView.
This study presents a dual‐module deep learning system for the design of near‐infrared (NIR) fluorophores. A large molecular library is generated and analyzed, leading to the suggestions of promising candidates. The effectiveness of the system is further validated through the synthesis, characterization, and in vivo imaging, demonstrating its potential
Yixin Zhu, Xia Ling, Xianhe Zhang, Chuanjiang Jian, Leilei Shi, Wentao Song, Xiaonan Wang, Bin Liu   +7 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Supplementary Table Legend from Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01

, 2005
Supplementary Table Legend from Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00 ...
Kathleen Lamborn (14980125), Richard Wilson (308436), Jeffrey R. Razier (14980116), Patrick Wen (285921), Lisa M. DeAngelis (14932475), Alan H. Shih (4925320), John K. Cowell (11838189), W.A. Yung (14980128), Frank S. Lieberman (10761360), Susan Chang (9317920), Michael R. Rossi (5371043), William Pao (25938), John G. Kuhn (3689071), Mark R. Gilbert (7271489), Michael Prados (8195838), Eric C. Holland (130584), Andrew B. Lassman (14980113), Norma J. Nowak (13037181), Lauren E. Abrey (14980119), Chelsea N. Grefe (14980122)   +19 more
core   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

HEAL AIDS WORLD AIDS DAY 12-01-00

, 2000
White t-shirt. Text: [Front] HEAL AIDS WORLD AIDS DAY 12-01-00 [Back] HEAL AIDS WITH Time Education Work Research Awareness Volunteering Money Understanding LOVE WORLD AIDS DAY 12-01-00https://digitalcommons.usm.maine.edu/lgbt_tshirts/1110/thumbnail ...

core   +1 more source

Supplementary Table 1 from Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01

, 2005
Supplementary Table 1 from Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00 ...
Kathleen Lamborn (14980125), Richard Wilson (308436), Jeffrey R. Razier (14980116), Patrick Wen (285921), Lisa M. DeAngelis (14932475), Alan H. Shih (4925320), John K. Cowell (11838189), W.A. Yung (14980128), Frank S. Lieberman (10761360), Susan Chang (9317920), Michael R. Rossi (5371043), William Pao (25938), John G. Kuhn (3689071), Mark R. Gilbert (7271489), Michael Prados (8195838), Eric C. Holland (130584), Andrew B. Lassman (14980113), Norma J. Nowak (13037181), Lauren E. Abrey (14980119), Chelsea N. Grefe (14980122)   +19 more
core   +1 more source