Results 151 to 160 of about 1,034,135 (309)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

H2Open Journal (2022) 5 (1): 26–42: Beyond inclusion: practical lessons on striving for gender and disability transformational changes in WASH systems in Cambodia and Timor-Leste. Chelsea Huggett, Livia Da Costa Cruz, Fraser Goff, Pharozin Pheng, Doeurn Ton https://doi.org/10.2166/h2oj.2022.039

H2Open Journal, 2022
doaj   +1 more source

Global, regional and national burden of maternal haemorrhage (2000-2021) and projections to 2050 in 204 countries and territories. [PDF]

BMJ Open
Ayele M, Duko B, Tiruye T, Ward PR, Mwanri L, Pereira G, Kitaw TA, Abate BB, Lake ES, Alamrew A, Yetwale A, Yilak G, Tilahun BD, Mulugeta C, Emagneneh T, Gebremedhin AT.   +15 more
europepmc   +1 more source

Carte de l'Afrique à l'échelle de 1:2 000 000. 04, Fez : Afrique (région septentrionale) / dressé et dessiné par... Régnauld de Lannoy de Bissy

, 1892
Échelle(s) : 1:2 000 ...
France. Service géographique de l'armée. Éditeur scientifique, Régnauld de Lannoy de Bissy, Richard de (1844-1906). Cartographe   +1 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Hydrology and water resources management in a changing world

Hydrology Research, 2020
Kolbjørn Engeland, Knut Alfredsen
doaj   +1 more source

The stress reduction potential of Bhagavad Gita and Yoga for healthcare workers during the COVID-19 pandemic: A randomized controlled trial. [PDF]

PLoS One
Das N, Konduru L, Dahia SS, Sagnika S, Kothari-Speakman G, Behura AK.   +5 more
europepmc   +1 more source

Carte de l'Afrique à l'échelle de 1:2 000 000. 14, Assouan : Afrique (région septentrionale) / [dressé et dessiné par Régnauld de Lannoy de Bissy]

, 1898
Échelle(s) : 1:2 000 ...
France. Service géographique de l'armée. Éditeur scientifique, Régnauld de Lannoy de Bissy, Richard de (1844-1906). Cartographe   +1 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Future-oriented technologies and concepts to increase water availability by water reuse and desalination

Journal of Water Reuse and Desalination, 2020
Jörg E. Drewes
doaj   +1 more source