Results 201 to 210 of about 10,198,141 (356)
Obtención de nuevos derivados de naftaleno como potenciales fármacos para la enfermedad de Alzheimer
La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo incurable que conduce, de manera irreversible, a la pérdida de las capacidades cognitivas y de la memoria, desorientación, trastornos del lenguaje y cambios de conducta.
Marquiza Sablón Carrazana
doaj
Twelve months of deputising: 100 000 patient contacts with eighteen services. [PDF]
R. A. Dixon, Brian T. Williams
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Flood Catastrophes in a Changing Environment
Qi Zhang, Zulkifli Yusop
doaj +1 more source
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci+6 more
wiley +1 more source
Sodium-Cooled 1, 000 MWe Fast Breeder Reactor Design Study (1st Cycle)
M. Nozawa
openalex +2 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Safety and Economic Characteristics of a 1, 000 MWe Fast Sodium-Cooled Reactor Design
Karl Cohen
openalex +2 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte+10 more
wiley +1 more source