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Phase II LEAP-004 Study of Lenvatinib Plus Pembrolizumab for Melanoma With Confirmed Progression on a Programmed Cell Death Protein-1 or Programmed Death Ligand 1 Inhibitor Given as Monotherapy or in Combination

Journal of Clinical Oncology, 2022
PURPOSE Effective treatments are needed for melanoma that progresses on inhibitors of programmed cell death protein-1 (PD-1) or its ligand (PD-L1).
A. Arance, L. de la Cruz-Merino, T. Petrella, R. Jamal, L. Ny, A. Carneiro, A. Berrocal, I. Márquez-Rodas, A. Spreafico, V. Atkinson, Fernanda Costa Svedman, A. Mant, M. Khattak, C. Mihalcioiu, S. Jang, C. Cowey, Alan D. Smith, N. Hawk, Ke Chen, Scott J. Diede, C. Krepler, G. Long   +21 more
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M-004

Grafías, disciplinares de la UCPR, 2022
La identificación de la manzana se hace mediante fases de observación, por medio de este proceso se hace más fácil sustraer la información concreta sin que se disperse o se torne abstracta. La primera fue referenciarla sobre el casco urbano de BuenaVista, se encuentra entre las carreras segunda y tercera sobre toda la calle tres, esta manzana se hace ...
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Computer-Aided Semi-Rational Design to Enhance the Activity of l-Sorbosone Dehydrogenase from Gluconobacter oxidans WSH-004.

Journal of Agricultural and Food Chemistry
The titer of the microbial fermentation products can be increased by enzyme engineering. l-Sorbosone dehydrogenase (SNDH) is a key enzyme in the production of 2-keto-l-gulonic acid (2-KLG), which is the precursor of vitamin C.
Dong Li, Xinglong Wang, Lin Huo, Weizhu Zeng, Jianghua Li, Jingwen Zhou   +5 more
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Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1–2 study

The Lancet, 2023
T. Siddiqi, D. Maloney, S. Kenderian, D. Brander, K. Dorritie, J. Soumerai, P. Riedell, N. Shah, R. Nath, B. Fakhri, D. Stephens, Shuo Ma, T. Feldman, S. Solomon, S. Schuster, S. Perna, S. Tuazon, S. Ou, E. Papp, Leanne Peiser, Yizhe Chen, W. Wierda   +21 more
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