A Comparison of the Antinociceptive Properties of SJP-005 and Morphine in Rats [PDF]
SJP-005 (a combination of ketotifen and ibuprofen) is being developed as a potential treatment for pain and for opioid use disorder. It is therefore important to investigate the potential antinociceptive properties of SJP-005.
Joris C Verster+3 more
doaj +6 more sources
Characterization of ML-005, a Novel Metaproteomics-Derived Esterase [PDF]
A novel gene encoding for a lipolytic enzyme, designated ML-005, was recently identified using a functional metaproteomics approach. We heterologously expressed this protein in Escherichia coli and biochemically characterized it.
Premankur Sukul+2 more
doaj +6 more sources
Background Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in women of reproductive age and is commonly complicated by adverse endometrial outcomes.
Xueying Zhang+8 more
doaj +2 more sources
Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression [PDF]
Background Migraine is a common neurovascular disorder that remains currently untreated in half of the patients. One third of migraine patients experience aura, which is associated with the development of cortical spreading depolarization (CSD), a wave ...
Flavia Brugia+8 more
doaj +2 more sources
The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model [PDF]
Proline-rich antimicrobial peptides (PrAMPs) have gained attention due to their antimicrobial properties and low cytotoxicity. B7-005, a small optimized PrAMP, exhibits a broader spectrum of activity than native PrAMPs, due to an antimicrobial mechanism ...
Adriana Di Stasi+12 more
doaj +2 more sources
Extracellular biosynthesis of silver nanoparticle using Streptomyces sp. 09 PBT 005 and its antibacterial and cytotoxic properties [PDF]
The application of microorganisms for the synthesis of nanoparticles as an eco-friendly and promising approach is welcome due to its non-toxicity and simplicity. The aim of this study was to synthesize silver nanoparticle using Streptomyces sp.
Pachaiyappan Saravana Kumar+5 more
openalex +2 more sources
Assessment of genetically modified maize GA21 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐005) [PDF]
Following the submission of application EFSA‐GMO‐RX‐005 under Regulation (EC) No 1829/2003 from Syngenta Crop Protection NV/SA, the Panel on Genetically Modified Organisms of the European Food Safety Authority (GMO Panel) was asked to deliver a ...
Hanspeter Naegeli+19 more
openalex +2 more sources
Spectropolarimetry of PKS 0040-005 and the orientation of broad absorption line quasar [PDF]
We have used the Very Large Telescope (VLT) to obtain spectropolarimetry of the radio-loud, double-lobed broad absorption line (BAL) quasar PKS 0040−005.
M. S. Brotherton+2 more
openalex +3 more sources
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients with extensive-stage small cell lung cancer (SCLC). It remained unknown whether adding a programmed cell death 1 (
Ying Cheng+24 more
semanticscholar +1 more source
Background Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a ...
Adriana Della Pietra+9 more
semanticscholar +1 more source