Results 1 to 10 of about 1,220,618 (361)
OR10-006 - Canakinumab in patients with TRAPS [PDF]
Pediatric Rheumatology, 2013 TNF-receptor associated periodic syndrome (TRAPS) is a rare, dominantly inherited periodic fever syndrome due to mutations of the TNFRSF1A gene. The IL-1 receptor antagonist anakinra has been reported to be an efficacious daily treatment. Canakinumab (CAN) is a fully human monoclonal selective anti-IL-1β antibody with a T1/2 of ~4 wks. Interim clinical
Helen J. Lachmann +8 more
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10.1007/s10955-006-9040-z [PDF]
Journal of Statistical Physics, 2006 We derive hydrodynamic equations describing the evolution of a binary fluid segregated into two regions, each rich in one species,which are separated (on the macroscopic scale) by a sharp interface. Our starting point is a Vlasov-Boltzmann (VB) equation describing the evolution of the one particle position and velocity distributions, fi (x, v, t), i ...
Raffaele Esposito +3 more
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P.006 Keeping neurosarcoidosis on the differential [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2016 Background: Sarcoidosis is a multiorgan autoimmune disease characterized by the presence of non-caseating granulomas. The diagnosis can be difficult, particularly with central nervous system (CNS) involvement, and pathology outside of the CNS has to be carefully evaluated.
H Leonard +6 more
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OR11-006 - A mutation in NLRP1A causes autoinflammation [PDF]
Pediatric Rheumatology, 2013 The NLRs (Nucleotide-binding domain and Leucine-rich repeat containing Receptors) are a family of intracellular innate immune receptors involved in host defense. Upon activation, NLRs form large protein complexes called “inflammasomes” that bind and activate Caspase-1, resulting in proteolytic activation of the pro-inflammatory cytokines pro-IL-1β and ...
Motti Gerlic +3 more
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An Efficient and Scalable Synthesis of Quinolone 006
Chemical and Pharmaceutical Bulletin, 2019 Quinolone 006 is under development as an anti-methicillin-resistant Staphylococcus aureus quinolone antibiotic. A linear synthetic route was utilized to prepare the compound on a multi-kilogram scale with an overall yield of 71%. The process was optimized by controlling the temperature and the vacuum pressure.
Xiao-guang Huang, Kun-nan Chen
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OR7-006 – Autophagy as a player in inflammation in TRAPS [PDF]
Pediatric Rheumatology, 2013 Tumor Necrosis Factor Receptor (TNFR) Associated Periodic Syndrome (TRAPS) is a dominant autoinflammatory disorder caused by heterozygous mutations in TNFRSF1A, the gene encoding the TNFalpha receptor 1 (TNFR1). TNFRSF1A mutations induce aberrant localization and accumulation in aggregates of the mutant TNFR1 proteins, elevated levels of reactive ...
E Di Zanni +12 more
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, 2021 Sexta edi o da nova Newsletter que trar informes dos desenvolvimentos mais recentes do Programa de Pesquisas Ecol gicas de Longa Dura o nos Campos Rupestre e Serra do Cip (PELD-CRSC).
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, 2011 Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960. Le sous-corpus "omelette" représente les 96 réponses à la question sur la recette de l'omelette posée au cours des entretiens en face-à-face.
Blanc, Michel +5 more
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6ER-006 Digital literacy in multiple sclerosis [PDF]
Section 6: Education and Research, 2020 Background and importance The emergence of new technologies has allowed great advances in the way we communicate. The hospital pharmacy can take advantage of these technologies available to the entire population to improve communication and access between healthcare professionals and patients.
A Ferrer Machín +10 more
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006 PP: COLLABORATION IN MUSEUMS AND HEALTH RESEARCH [PDF]
UCL QUALITATIVE HEALTH RESEARCH SYMPOSIUM 2017, 2017 This study reflects on the range of collaborations in two distinct but thematically linked UCL research projects which consider the role of culture in health promotion: Museums on Prescription (2014–2017), in partnership with Canterbury Christ Church University, explores the value of heritage encounters in social prescribing for lonely older adults at ...
Paul M. Camic +6 more
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