Results 131 to 140 of about 1,398,610 (367)

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

The Role of Intraligand Charge Transfer Processes in Iridium(III) Complexes with Morpholine-Decorated 4′-Phenyl-2,2′:6′,2″-terpyridine

Molecules
To investigate the impact of the electron-donating morpholinyl (morph) group on the ground- and excited-state properties of two different types of Ir(III) complexes, [IrCl3(R-C6H4-terpy-κ3N)] and [Ir(R-C6H4-terpy-κ3N)2](PF6)3, the compounds [IrCl3(morph ...
Joanna Palion-Gazda, Aleksandra Kwiecień, Katarzyna Choroba, Mateusz Penkala, Anna Kryczka, Barbara Machura   +5 more
doaj   +1 more source

q.02, Image 006

, 2023
:unav
openalex   +1 more source

Broadband All‐Optical Memtransistor Based on Organic Cocrystals for Noise‐Robust Motion Recognition

Advanced Science, EarlyView.
This work presents an all‐optical synaptic transistor using DTT‐TCNQ organic charge transfer cocrystals, achieving broadband bidirectional modulation (395–808 nm) with highly linear synaptic plasticity (nonlinearity coefficients αp = 0.00191, αd = 0.00305).
Zhaohui Cai, Yuxiao Fang, Wenjie Du, Zhengjun Liu, Yingli Shi, Jiahua Luo, Rui Wu, Lixing Kang, Chun Zhao   +8 more
wiley   +1 more source

DELETE 006

Ûridičnij časopis Nacìonalʹnoï akademìï vnutrìšnìh sprav, 2022
openaire   +1 more source

Clinical characteristics and clinicopathological correlations of bilateral breast cancer in China: A multicenter study from Chinese Society of Breast Surgery (CSBrS-006)

, 2021
Xuelu Li, Yitong Wang, Bo Pan, Man Li, Jiyue Gao, Yi Zhao, Zuowei Zhao, Chinese Society Of Breast Surgery   +7 more
openalex   +1 more source

Dual‐Site Synergistic Mechanism via Single‐Atom and Vacancy Drives Lattice Oxygen Activation in Layered Double Hydroxides

Advanced Science, EarlyView.
A strategy utilizing high‐energy ion beam technology to engineer defects in layered double hydroxide (LDH) nanosheets enables the high loading of non‐noble metal Mo single atoms. The synergistic effect between oxygen vacancies and single atoms promotes a novel mechanism for lattice oxygen activation, thereby significantly enhancing the oxygen evolution
Shixin Wu, Wenyu Lu, Shijun Zhao, Kai Zhao, Ning Yan, Liqiu Huang, Derun Li, Tao Jiang, Hengyi Wu, Feng Ren   +9 more
wiley   +1 more source

Sulfate‐Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS‐Based Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with long‐term stability, reproducibility, and sub‐picomolar sensitivity. Sulfate ions guide anisotropic growth and protect the surface, enabling improved performance over 7 months under ambient conditions.
Aradhana Dwivedi, Jan Dellith, Anna Makarova, Samir F. El‐Mashtoly, Juergen Popp, Vladimir Sivakov, Dana Cialla‐May   +6 more
wiley   +1 more source

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study.

The Lancet Oncology, 2019
C. Robert, A. Ribas, J. Schachter, A. Arance, J. Grob, L. Mortier, A. Daud, M. Carlino, C. McNeil, M. Lotem, J. Larkin, P. Lorigan, B. Neyns, C. Blank, T. Petrella, O. Hamid, Shu-Chih Su, C. Krepler, N. Ibrahim, G. Long   +19 more
semanticscholar   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source