Results 11 to 20 of about 41,988 (241)

Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAFV600E dual targeted inhibitor against melanoma

Oncology Research, 2022
Malignant melanoma is characterized by both genetic and molecular alterations that activate phosphoinositide 3-kinase (PI3K), and RAS/BRAF pathways. In this work, through diversity-based high-throughput virtual screening we identified a lead molecule ...
Faisal H Tobeigei, Reem M. Gahtani, Ahmad Shaikh, A. Al Ali, N. Kameli, H. Kamli, Prasanna Rajagopalan   +6 more
semanticscholar   +1 more source

Collimated synchrotron threads linking the radio lobes of ESO 137-006 [PDF]

Astronomy & Astrophysics, 2020
We present MeerKAT 1000 MHz and 1400 MHz observations of a bright radio galaxy in the southern hemisphere, ESO 137-006. The galaxy lies at the centre of the massive and merging Norma galaxy cluster.
M. Ramatsoku, M. Murgia, V. Vacca, P. Serra, S. Makhathini, F. Govoni, O. Smirnov, L. Andati, E. D. Blok, G. J'ozsa, P. Kamphuis, D. Kleiner, F. Maccagni, D. C. Moln'ar, A. Ramaila, K. Thorat, S. White   +16 more
semanticscholar   +1 more source

Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: S-methyl L-cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in Alium plants such as, garlic and onion. Objectives: The present study was aimed to evaluate the hypoglycemic and antihyperlipidemic properties of ...
Senthilkumar G.P., Sithara Thomas, Sivaraman K., Sankar P., Zachariah Bobby   +4 more
doaj   +1 more source

Identification of a Novel Insertion Site HVT-005/006 for the Generation of Recombinant Turkey Herpesvirus Vector

Frontiers in Microbiology, 2022
Turkey herpesvirus (HVT) has been widely used as a successful live virus vaccine against Marek's disease (MD) in chickens for more than five decades. Increasingly, HVT is also used as a highly effective recombinant vaccine vector against multiple avian ...
Xusheng Zai, Bin Shi, H. Shao, Kun Qian, Jianqiang Ye, Yongxiu Yao, V. Nair, A. Qin   +7 more
semanticscholar   +1 more source

Long-term outcomes in patients with advanced melanoma who had initial stable disease with pembrolizumab in KEYNOTE-001 and KEYNOTE-006

European Journal of Cancer, 2021
Objective: Patients with melanoma and early stable disease (SD) with pembrolizumab have unclear prognosis. We present post hoc analyses of long-term outcomes for patients with early SD, partial response (PR) or complete response (CR) with pembrolizumab ...
O. Hamid, C. Robert, A. Daud, M. Carlino, T. Mitchell, P. Hersey, J. Schachter, G. Long, F. Hodi, J. Wolchok, A. Arance, J. Grob, A. Joshua, J. Weber, L. Mortier, E. Jensen, Scott J. Diede, B. H. Moreno, A. Ribas   +18 more
semanticscholar   +1 more source

Experimental assessment of physicochemical properties of L-phenylalanine and L-arginine in (water + 1-butyl-3-methylimidazolium bromide / tributylmethylammonium chloride) solutions at various temperatures

Chemical Thermodynamics and Thermal Analysis, 2022
The experimental data from acoustic, volumetric, and viscometric studies has been used to investigate significant changes in two amino acids, L-phenylalanine and L-arginine, in aqueous solutions of two ionic liquids, 1-butyl-3-methylimidazolium bromide, [
Dinesh Kumar, Shahid Shafi Shah, Taniya Sharma, Devinder Singh, Rajinder K Bamezai   +4 more
doaj   +1 more source

Influence of tillage and fertilizer management practices on productivity and resource use efficiency of groundnut (Arachis hypogaea) in Thar Desert of Rajasthan

The Indian Journal of Agricultural Sciences, 2022
Conventional tillage practices in Thar Desert of Rajasthan are posing a serious threat of natural resource degradation due to soil erosion induced by high temperature and winds.
TANUJA POONIA, S M KUMAWAT, S R BHUNIA, S K JOHRI   +3 more
doaj   +1 more source

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study.

The Lancet Oncology, 2019
BACKGROUND Pembrolizumab improved progression-free survival and overall survival versus ipilimumab in patients with advanced melanoma and is now a standard of care in the first-line setting.
C. Robert, A. Ribas, J. Schachter, A. Arance, J. Grob, L. Mortier, A. Daud, M. Carlino, C. McNeil, M. Lotem, J. Larkin, P. Lorigan, B. Neyns, C. Blank, T. Petrella, O. Hamid, Shu-Chih Su, C. Krepler, N. Ibrahim, G. Long   +19 more
semanticscholar   +1 more source

Yield loss assessment in rice (Oryza sativa) due to false smut infection

The Indian Journal of Agricultural Sciences, 2020
Rice false smut caused by Ustilaginoidea virens is a destructive inflorescence disease threatening rice production worldwide. The disease is emerging in many rice growing countries including India.
MATHEW S BAITE, RAGHU S, PRABHUKARTHIKEYAN S R, ARUP K MUKHERJEE, MANAS K BAG, MAYABINI JENA   +5 more
doaj   +1 more source

Detection of Brucella melitensis in milk and serum samples of goats by serological and molecular techniques

Indian Journal of Animal Sciences, 2023
The present investigation was planned for the detection of brucellosis in goats using serological and molecular techniques. A total of 500 clinical samples (250 milk and 250 serum) of goats were collected. All the milk samples were screened by Milk Ring
SWAPNIL LONKAR, VARSHA THORAT, RAJASHREE GANDGE, RAJESH PHARANDE, SANDEEP GAIKWAD   +4 more
doaj   +1 more source