Results 81 to 90 of about 1,392,476 (289)

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

First measurement of the spectral function at high energy and momentum in medium-heavy nuclei

, 2006
The experiment E97-006 was performed at Jefferson Lab to measure the momentum and energy distribution of protons in the nucleus far from the region of the (approximate) validity of the mean field description, i.e. at high momentum and energies.
Abbott, Barbieri, Barbieri, Benhar, Benhar, Benhar, Benhar, D. Rohe, de Forest, de Witt Huberts, Ent, Frick, Frick, Garino, Garrow, Hassaneen, Konrad, Mougey, Müther, Müther, O'Neill, Rohe, Rohe, Van Orden   +23 more
core   +1 more source

Humanizing psychotherapy [PDF]

, 2007
The essence of the humanistic and existential approaches to psychotherapy is a commitment to conceptualizing, and engaging with people in a deeply valuing and respectful way.
Cooper, Mick
core   +1 more source

Tunable Negative Thermal Expansion in Fe/Cr‐Substituted Nd2Co17 Compounds via Magnetoelastic Coupling

Advanced Science, EarlyView.
This study achieves anisotropic thermal expansion tuning in Nd2(Co1‐xFex)17‐yCry compounds via a magnetoelastic strategy. Variable‐temperature synchrotron X‐ray diffraction reveals that increased Fe content induces switchable lattice responses. Compositional control reduces the volume expansion coefficient αV by 20% (x═0.7) and modulates TC (442–625 K),
Jiayuan Li, Chenfei Qv, Haoran Tu, Qinfen Gu, Wayne D. Hutchison, Stewart J. Campbell, Zhenxiang Cheng, Wenquan Wang, Jianli Wang   +8 more
wiley   +1 more source

Stylar end browning: a physiological disorder of Indian jujube (Ziziphus mauritiana) fruits

The Indian Journal of Agricultural Sciences, 2016
A physiological disorder has been noted in Indian jujube or ber (Ziziphus mauritiana Lamk.) cv. Chhuhara, wherein tip (stylar end) of the ber fruits turned brown. The disorder has been found to aggravate with the progress in the maturity.
HARE KRISHNA, BRIJESH DUTT SHARMA, RAKESH BHARGAVA, RAMA SHANKER SINGH   +3 more
doaj   +1 more source

Highly Robust Sn‐Based MAX Anodes Constructed via Ti6C Octahedral Outer Immobilization and A‐Layer Fe Inner Anchoring for Long‐Life Lithium‐Ion Batteries

Advanced Science, EarlyView.
How can Sn‐based anodes achieve high capacity and long‐life cycling? This work unlocks the potential anode structure by confining Sn in the A layer of MAX phase with Ti6C octahedra as outer immobilization and Fe as inner anchors. The introduction of Fe dramatically strengthens the Ti–Sn bond to enhance structural integrity, modulate interfacial ...
Yu‐ang Lei, Yuchen Guo, Linkai He, Yi Tang, Junhui Zou, Yangyang Xie, Xiaodie Xuan, Zhao Bi, Yu Wang, Ting Liu, Yunqing Kang, Taotao Ai, Yusuke Yamauchi, Chenhui Yang   +13 more
wiley   +1 more source

1-(2′-Ethoxy-4′-fluoro-[1,1′-biphenyl]-4-yl)-4-phenyl-1H-1,2,3-triazole

IUCrData, 2016
In the title compound, C22H18FN3O, the triazole ring is planar. The plane of the triazole ring makes dihedral angles of 19.31 (10), 20.52 (10) and 39.82 (9)° with the planes of the benzene rings, indicating the overall nonplanarity of the molecule.
Maryam Gilandoust, S. Naveen, K. B. Harsha, N. K. Lokanath, K. S. Rangappa   +4 more
doaj   +1 more source

An oral multiparticulate, modified-release, hydrocortisone replacement therapy that provides physiological cortisol exposure [PDF]

, 2014
Objective It is not possible with current hydrocortisone replacement to mimic the diurnal cortisol profile in patients with adrenal insufficiency. Previous attempts with modified-release technology were unsuccessful.
Arlt, Bensing, Bergthorsdottir, Bryan, Clark, Debono, Finkielstain, Johannsson, Krieger, Kushnir, Lennernas, Lovas, Lovas, Mah, Merza, Moeller, Newell-Price, Plat, Roberts, Simon, Spiegel, Tomlinson, Tunn, Verma   +23 more
core   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

2-(3,4-Dimethoxyphenyl)-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine

Acta Crystallographica Section E, 2014
In the title compound, C21H19NO2S2, the seven-membered thiazepine ring adopts a slightly distorted twist boat conformation. The dihedral angle between the benzene rings is 67.4 (2)°. The mean plane of the thiophene ring is twisted by 59.3 (2) and 87.7 (2)
B. C. Manjunath, M. Manjula, K. R. Raghavendra, S. Shashikanth, K. Ajay Kumar, N. K. Lokanath   +5 more
doaj   +1 more source