Results 121 to 130 of about 2,061,547 (287)

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

O-020

Epidemiology, 2012
Sun-Young Kim, Joel Kaufman, Lianne Sheppard, Silas Bergen, Adam Szpiro, Ana Diez Roux, Joseph Polak, Sverre Vedal   +7 more
openaire   +2 more sources

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

020 - Global Rating

, 1966
Die Probanden wurden aufgrund der Exploration, der Testuntersuchung nach Mierke, den Beobachtungen bei den Ausflügen und gelegentlichen Gesprächen von den Versuchsleitern beurteilt. Sie legen den Gesamteindruck fest, wie die Probanden also im Allgemeinen während der Untersuchungen und der Ausflüge auftraten.
Lehr, Ursula, Thomae, Hans, Leinich, Lena   +2 more
openaire   +2 more sources

Tuning Desolvation Kinetics with Perovskite‐Type Ion‐Conductive Modulators toward Low‐Temperature Zn Metal Batteries

Advanced Science, EarlyView.
A strategy of constructing perovskite‐type ion‐conductive interphase modulation layer is proposed to break down ion‐dipole interactions of [Zn(H2O)x]2+ to promote Zn2+ desolvation and diffusion kinetics against dendrite growth and active water‐induced hydrogen evolution reactions.
Wenbin Wang, Xiaomin Cheng, Jing Zhang, Shuang Cheng, Zhenjiang Cao, Caiyin You, Yongzheng Zhang, Hao Li, Bixian Chen, Qinghua Guan, Yixiang Shi, Huihua Li, Qingbo Xiao, Hongzhen Lin, Jian Wang   +14 more
wiley   +1 more source

The foot-controlled maneuvering unit: Summary report on Skylab experiment T-020 [PDF]

Skylab experiment T-020 was conducted to study the maneuvering capabilities of astronauts using a relatively simple experimental self-locomotive device, referred to as the foot-controlled maneuvering unit, and to evaluate the effectiveness of ground ...
Glover, K. E., Hewes, D. E.
core   +1 more source

Multi‐Physical Field Modulated P‐Bit Device Based on VO2 Thin Film

Advanced Science, EarlyView.
We have proposed a VO2‐based P‐bit device where synergistic multi‐physical field modulation enables real‐time tunability of randomness. Besides introducing a new phase‐change material‐based device approach for high‐performance P‐bits, this study also demonstrates a synergistic multi‐physical field modulation strategy that opens new opportunities for ...
Bowen Sun, Jianjun Li, Ting Zhou, Jinglin Zhu, Meiling Liu, Zhihan Lin, Chang Wang, Chengyu Li, Yingxue Chen, Xiaokun Huo, Chongwen Zou   +10 more
wiley   +1 more source

Print, Eat, Heal: Unravelling the Potential of Bioactives in 3D Food Technology

Foods
3D-printed food (3DPF) is on the rise, enabling the development of new food products. Current applications in this domain led to the replication of meat analogs, protein-enriched products, and dietary solutions tailored to address nuanced health ...
Monize Bürck, Monica Masako Nakamoto, Sergiana dos Passos Ramos, Marcelo Assis, Anna Rafaela Cavalcante Braga   +4 more
doaj   +1 more source