Results 251 to 260 of about 70,570 (281)

Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model

Antimicrobial Agents and Chemotherapy, 2023
BTZ-043, a suicide inhibitor of the Mycobacterium tuberculosis cell wall synthesis decaprenylphosphoryl-beta-D-ribose 2′ epimerase, is under clinical development as a potential new anti-tuberculosis agent.
Michelle E Ramey, Allison A Bauman, Lisa M Massoudi   +2 more
exaly   +2 more sources

Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model

Antimicrobial Agents and Chemotherapy, 2023
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is the world’s leading cause of mortality from a single bacterial pathogen. With increasing frequency, emergence of drug-resistant mycobacteria leads to failures of standard TB treatment regimens ...
Max Bastian
exaly   +2 more sources

SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways

Current Issues in Molecular Biology
Objective: Non-small cell lung cancer (NSCLC) remains one of the most significant contributors to cancer-related mortality. This investigation explores the influence and underlying mechanisms of the USP1 inhibitor SJB2-043 on A549 cells, with the aim of ...
Huajian Li, Xuejing Jia, Yuanye Dang
exaly   +2 more sources

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Ochratoxin A degrading enzymes of Stenotrophomonas sp. 043-1a.

FEMS Microbiology Letters, 2023
Ochratoxin A is a secondary metabolite, which acts as mycotoxin and is produced by Aspergillus, Penicillium and other fungal species. It is a threat to animal and human health due to nephrotoxic, carcinogenic, and genotoxic properties and its widespread ...
Christoph Gonaus, L. Wieland, G. Thallinger, S. Prasad   +3 more
semanticscholar   +1 more source