Results 51 to 60 of about 69,946 (217)

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis

open access: yesNature Communications
The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark of human tuberculosis (TB). New anti-TB therapies need to effectively penetrate the cellular and necrotic compartments of these lesions and ...
Andreas Römpp   +23 more
doaj   +1 more source

Sema4A neutralization reduces fibrosis and inflammation in a mouse model of systemic sclerosis and a 3D model of immunity‐driven fibrosis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective We previously showed that Semaphorin4A (Sema4A) is elevated in patients with systemic sclerosis (SSc) and promotes inflammation and fibrosis in vitro. Here, we examined the effect of Sema4A neutralization in vivo and in 3D fibrosis models. Methods Sema4A plasma levels were measured by ELISA in healthy controls (n=31) and patients with SSc (n=
Jaime Marty   +21 more
wiley   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen   +4 more
wiley   +1 more source

Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry   +3 more
wiley   +1 more source

Modelling the Incremental Value of Personality Facets: The Domains‐Incremental Facets‐Acquiescence Bifactor Model

open access: yesEuropean Journal of Personality, EarlyView., 2020
Abstract Personality can be described at different levels of abstraction. Whereas the Big Five domains are the dominant level of analysis, several researchers have called for more fine‐grained approaches, such as facet‐level analysis. Personality facets allow more comprehensive descriptions, more accurate predictions of outcomes, and a better ...
Daniel Danner   +4 more
wiley   +1 more source

Who Knows Best What the Next Year Will Hold for You? The Validity of Direct and Personality‐based Predictions of Future Life Experiences Across Different Perceivers

open access: yesEuropean Journal of Personality, EarlyView., 2020
Abstract This study explored the validity of person judgements by targets and their acquaintances (‘informants’) in longitudinally predicting a broad range of psychologically meaningful life experiences. Judgements were gathered from four sources (targets, N = 189; and three types of informants, N = 1352), and their relative predictive validity was ...
Nele M. Wessels   +3 more
wiley   +1 more source

Situation Report 043. [PDF]

open access: yes, 2020
Corona virus disease 2019 (COVID-19) Situation Report – 043 highlights in Ethiopia and ...

core  

Combined Use of Multi-Temporal Optical and Radar Satellite Images for Grassland Monitoring

open access: yesRemote Sensing, 2014
The aim of this study was to assess the ability of optical images, SAR (Synthetic Aperture Radar) images and the combination of both types of data to discriminate between grasslands and crops in agricultural areas where cloud cover is very high most of ...
Pauline Dusseux   +3 more
doaj   +1 more source

Knowledge Sharing in the Mining Sector: Unlocking Employee Ambidexterity Through Psychological and Environmental Mediating Factors

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study examines how and why individual knowledge sharing fosters ambidextrous behavior among nonmanagerial employees in an operationally intensive, environmentally sensitive industry. We conducted a survey of 243 operators across 10 plants of an international lime producer, finding that knowledge sharing is positively related to individual
Laurent Scaringella   +2 more
wiley   +1 more source

Corrosion Inhibition of Mild Steel in Acid Solution by 3,4,5-Trimethoxyphenyl-2-imidazolines

open access: yesE-Journal of Chemistry, 2011
A heterocyclic imidazoline, 3,4,5-trimethoxyphenyl-2-imidazolines (TMP2I) was tested for its corrosion inhibition in 0.5 M H2SO4 and 1 M HCl using weight loss, Tafel polarisation and electrochemical impedance techniques.
D. Nalini, R. Rajalakshmi, S. Subhashini
doaj   +1 more source

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