Results 11 to 20 of about 42,942 (101)

GX15-070 enhances niraparib efficacy in ovarian cancer by promoting a shift in Mcl1-mediated DNA repair pathway from HR to NHEJ [PDF]

Journal of Translational Medicine
Background PARP inhibitor (PARPi) maintenance therapy significantly extends progression-free survival of patients with homologous recombination repair deficiency (HRD) or BRCA mutations in ovarian cancer.
Jia-Jia Sheng, Yan He, Po-Wu Liu, Sheng-An Zheng, Nayiyuan Wu, Hong-Ying Sui, Quan Cheng, He Li   +7 more
doaj   +2 more sources

Coadjuvant Anti-VEGF A Therapy Improves Survival in Patients with Colorectal Cancer with Liver Metastasis: A Systematic Review

Gastrointestinal Disorders, 2020
Background: the presence of liver metastasis in colorectal cancer (CRC) remains one of the most significant prognostic factors. Objective: systematically review the results of studies evaluating the benefit of adding bevacizumab to a normal chemotherapy ...
Isabel Novo, Bárbara Campos, Filipa Pinto-Ribeiro, Sandra F. Martins   +3 more
doaj   +1 more source

GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

BMC Cancer, 2019
Background Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance.
Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal, Hervé Sartelet   +9 more
doaj   +1 more source

Performance Analysis of Interval Type-2 Fuzzy $\overline{\mathbf{X}}$ and R Control Charts

Applied Sciences, 2023
Statistical process control (SPC) is one of the most powerful techniques for improving quality, as it is able to detect special causes of problems in processes, products and services with a remarkable degree of accuracy. Among SPC tools, X¯ and R control
Túlio S. Almeida, Amanda dos Santos Mendes, Paloma M. S. Rocha Rizol, Marcela A. G. Machado   +3 more
doaj   +1 more source

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components. [PDF]

PLoS ONE, 2013
BACKGROUND: Owing to their important function in regulating cell death, pharmacological inhibition of Bcl-2 proteins by dubbed BH3-mimetics is a promising strategy for apoptosis induction or sensitization to chemotherapy. However, the role of Apaf-1, the
Vicente Andreu-Fernández, Ainhoa Genovés, Angel Messeguer, Mar Orzáez, Mónica Sancho, Enrique Pérez-Payá   +5 more
doaj   +1 more source

Intracranial Compliance Assessed by Intracranial Pressure Pulse Waveform

Brain Sciences, 2021
Background: Morphological alterations in intracranial pressure (ICP) pulse waveform (ICPW) secondary to intracranial hypertension (ICP >20 mmHg) and a reduction in intracranial compliance (ICC) are well known indicators of neurological severity.
Sérgio Brasil, Davi Jorge Fontoura Solla, Ricardo de Carvalho Nogueira, Manoel Jacobsen Teixeira, Luiz Marcelo Sá Malbouisson, Wellingson Silva Paiva   +5 more
doaj   +1 more source

Evaluation of the Microbial Profile on the Polydioxanone Membrane and the Collagen Membrane Exposed to Multi-Species Subgingival Biofilm: An In Vitro Study

Membranes, 2023
Dehiscence in surgeries involving membranes often leads to bacterial contamination, hindering the healing process. This study assessed bacterial colonization on various membrane materials.
Marcus Vinícius Cintra Moreira, Luciene C. Figueiredo, Marcelo Augusto Ruiz da Cunha Melo, Fabio Hideaki Uyeda, Lucas Daylor Aguiar da Silva, Tatiane Tiemi Macedo, Roberto Sacco, Carlos Fernando Mourão, Jamil A. Shibli, Bruno Bueno-Silva   +9 more
doaj   +1 more source

La evaluación según Ley 070 ASEP en la educación secundaria

Revista Franz Tamayo, 2023
La educación en Bolivia viene desarrollando planificaciones estratégicas, dando cumplimiento a las diferentes reformas y modelos educativos. Este trabajo tuvo como objetivo analizar la evaluación integral según la Ley 070 ASEP en el proceso de enseñanza ...
Juan Pablo Mollo-Torrico, Rodrigo Mendoza Montemayor   +1 more
doaj   +1 more source

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review

Foods, 2023
Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant and anti-inflammatory action.
Andressa Roehrig Volpe-Fix, Elias de França, Jean Carlos Silvestre, Ronaldo Vagner Thomatieli-Santos   +3 more
doaj   +1 more source

A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice

Frontiers in Cardiovascular Medicine
IntroductionTotum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases.
Cédric Langhi, Marie Vallier, Auriane Bron, Yolanda F. Otero, Maheva Maura, Florian Le Joubioux, Niek Blomberg, Martin Giera, Bruno Guigas, Thierry Maugard, Benoit Chassaing, Sébastien Peltier, Stéphanie Blanquet-Diot, Jean-Marie Bard, Pascal Sirvent   +14 more
doaj   +1 more source