Results 81 to 90 of about 12,888 (222)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

From temple to house-church in Luke-Acts: a Lukan challenge to Korean Christianity [PDF]

open access: yes, 2012
This dissertation examines the portrayals of the Temple, synagogue, and house-churches in Luke-Acts to pose a Lukan challenge to the Korean church by using a model of architectural space which is derived from social-scientific ideas originating in ...
Jung, Young-San
core  

Use case scenarios and preliminary reference model [PDF]

open access: yes, 2007
This document provides the starting point for the development of dependability solutions in the HIDENETS project with the following contents: (1) A conceptual framework is defined that contains the relevant terminology, threats and general requirements ...
Radimirsch, M.   +7 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Spatial Consistency and Contextual Cues for Incidental Learning in Browser Design [PDF]

open access: yes
This paper introduces the Backward Highlighting technique for mitigating an identified flaw in directional column-faceted browsers like iTunes. Further, the technique significantly enhances the information that can be learned from the columns and ...
André, Paul   +3 more
core  

The recontextualisation of architecture and accounting education: Views from the academy and the professions [PDF]

open access: yes, 2014
This thesis reports on a study of the relationship between practice and higher education. It examines the nature of architecture and accounting professional disciplinary knowledge following the recontextualisation and shift of professional learning into ...
Blickem, Chelsea Jane
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Understanding the achievement of radical process orientation : an interpretive approach [PDF]

open access: yes, 1999
The achievement of radical process orientation is vital to the strategic and operational integrity of organisations. However, organisations have a dismal record of implementing process orientation, especially when it involves radical organisational ...
Braganza, A., Braganza, Ashley
core  

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