Results 131 to 140 of about 159,016,183 (278)
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The 1-2-3 conjecture for polygonal tilings
The 1-2-3 conjecture has been solved positively in 2024 for finite graphs and by extension for infinite graphs which are locally finite. The solution is non-constructive, and finding explicit solutions for large (or infinite) graphs is very hard. By exploiting the extra structure present in many non-periodic tilings, we find explicit solutions for the ...
Charlesworth, Alison +2 more
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
On the Extended 1-2-3 Conjecture of Pilz
We resolve (for all sufficiently large $n$) a conjecture of Pilz on the symmetric difference $AΔ(2A)Δ\cdotsΔ(nA)$ for finite sets $A\subseteq \mathbb{N}$ of positive integers. We show that this set always has cardinality at least $n$ for large $n$.
Holdridge, Philippa, Pach, Péter Pál
openaire +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2009 A weighting of the edges of a graph with integer weights gives rise to a weighting of the vertices, the weight of a vertex being the sum of the weights of its incident edges.
Karonski, Michal
core
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
On Convex Subcomplexes of Spherical Buildings and Tits’ Center Conjecture [PDF]
, 2009 In this thesis we study convex subcomplexes of spherical buildings. In particular, we are interested in a question of J. Tits which goes back to the 50’s, the so-called Center Conjecture.
Ramos Cuevas, Carlos
core +1 more source