IN VITRO AND IN VIVO DISPOSITION OF 2,2-DIMETHYL-N-(2,4,6- TRIMETHOXYPHENYL)DODECANAMIDE (CI-976) Identification of a Novel Five-Carbon Cleavage Metabolite in Rats [PDF]
, 2020 : The metabolism of CI-976, a potent inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase, was investigated in isolated rat hepatocytes and Wistar rats after oral administration. The major metabolite observed both in vitro and in
AND Bharat K Trivedi +5 more
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Novel perfluorinated compounds in the environment [PDF]
, 2022 Perfluorinated compounds are a broad class of manmade chemicals. Even though they have been linked to hepatotoxicity, neurotoxicity, nephrotoxicity and carcinogenicity, the mechanism of toxicity still remains unclear.
Leifertová, Karolína
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Molecular and functional characterization of sn-glycerol-3-phosphate acyltransferase of plants [PDF]
, 2011 sn-Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the acylation of sn-1 position of sn-glycerol-3-phosphate to produce lysophosphatidic acid and Coenzyme A.
Chen, Xue
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Per- and polyfluoroalkyl substances (PFAS) in ski products: Environmental contamination, bioaccumulation and effects in rodents [PDF]
, 2021 Per- and polyfluoroalkyl substances (PFAS) are a group of anthropogenic contaminants that are widespread in the environment. Due to the strong persistency and water and lipid repellency, PFAS have been used in a wide range of industrial processes and ...
Grønnestad, Randi
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The EF-hand Ca²⁺-binding protein super-family: A genome-wide analysis of gene expression patterns in the adult mouse brain [PDF]
, 2015 In mice, 249 putative members of the superfamily of EF-hand domain Ca²⁺-binding proteins, manifesting great diversity in structure, cellular localization and functions have been identified.
Celio, Marco R. +3 more
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Role of cytosolic acyl-CoA binding protein in seed oil biosynthesis [PDF]
, 2009 Acyl-CoA binding protein (ACBP) ubiquitously found in eukaryotic organisms fulfills important functions of solubilisation, protection and transport of acyl-CoA esters, a major intermediate of lipid metabolism. This thesis presents an investigation of the
Yurchenko, Olga
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Studies on the regulation of fatty acid biosynthesis by drugs [PDF]
, 2003 ラット肝臓において、オレイン酸の合成はエネルギー代謝と密接に関係している。抗高脂血症薬であるクロフィブリン酸や、ステロイドホルモンの一種であるデヒドロエピアンドロステロン(DHEA)は肝臓において、Δ9不飽和化酵素(SCD)とパルミトイル-CoA炭素鎖伸長酵素(PCE)を誘導し、肝臓におけるオレイン酸の割合を顕著に増加させ、逆にリノール酸やドコサヘキサエン酸の割合を低下させた。グルコースやフルクトースの負荷によってオレイン酸やパルミトオレイン酸の割合が増加し、リノール酸やアラキドン酸の割合が低下した ...
川嶋, 洋一
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Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast [PDF]
, 2022 Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition
Aiba, Hirofumi +6 more
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A systems biology approach for the study of smoking and myocardial infarction [PDF]
, 2015 Metabolomics has been proven to be a powerful tool to study complex phenotypes. It can present a snapshot of the current status of metabolism and provide a functional readout of the gene products.
Xu, Tao
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Positional Distribution of Fatty Acids in Plant Triacylglycerols: Contributing Factors and Chromatographic/Mass Spectrometric Analysis [PDF]
, 2010 Siirretty ...
Leskinen, Heidi
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